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   Articles with "gef" as a keyword



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securPharm e. V. – der Schutzschild gegen gefälschte Arzneimittel

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recommendations! Published in 2017 at "Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"

DOI: 10.1007/s00103-017-2628-4

Abstract: ZusammenfassungDas erklärte Ziel der Fälschungsschutzrichtlinie 2011/62/EU ist es, den Schutz von Patienten vor gefälschten Arzneimitteln weiter zu verbessern. Sie legt daher Maßnahmen fest, mit denen Fälschungen in der Lieferkette leichter erkannt werden können. Der europäische… read more here.

Keywords: von; falsified medicines; gef; der ... See more keywords
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Bildgebende Darstellung hirnversorgender Gefäße

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recommendations! Published in 2017 at "Der Internist"

DOI: 10.1007/s00108-017-0280-6

Abstract: ZusammenfassungFür die Bildgebung der hirnversorgenden Gefäße stehen heute mehrere technisch ausgereifte Verfahren zur Verfügung. In der Akutsituation eines Schlaganfalls kommt der computertomographischen Angiographie eine überragende Bedeutung zu, da aus ihr die Indikation zur intrakraniellen katheterbasierten… read more here.

Keywords: die; ultrasound imaging; gef; bildgebende darstellung ... See more keywords
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Modeling the Dynamics of Cdc42 Oscillation in Fission Yeast.

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recommendations! Published in 2018 at "Biophysical journal"

DOI: 10.1016/j.bpj.2017.12.007

Abstract: Regulation of polarized cell growth is essential for many cellular processes, including spatial coordination of cell morphology changes during growth and division. We present a mathematical model of the core mechanism responsible for the regulation… read more here.

Keywords: cell; gef; model; growth ... See more keywords
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Molybdenum disulfide-based hyaluronic acid-guided multifunctional theranostic nanoplatform for magnetic resonance imaging and synergetic chemo-photothermal therapy.

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recommendations! Published in 2019 at "Journal of colloid and interface science"

DOI: 10.1016/j.jcis.2019.04.022

Abstract: The construction of multifunctional theranostic nanoplatforms to integrate accurate imaging and enhanced therapy to treat tumors is highly attractive but remains a challenge. Here, we developed a molybdenum disulfide (MoS2)-based hyaluronic acid (HA)-functionalized nanoplatform capable… read more here.

Keywords: multifunctional theranostic; gef; synergetic chemo; chemo photothermal ... See more keywords
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Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study

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recommendations! Published in 2020 at "Journal of Ginseng Research"

DOI: 10.1016/j.jgr.2019.05.013

Abstract: Background Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role… read more here.

Keywords: effects gintonin; vitro vivo; gef; hair ... See more keywords
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Molecular mechanism of interactions between inhibitory tripeptide GEF and angiotensin-converting enzyme in aqueous solutions by molecular dynamic simulations

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recommendations! Published in 2018 at "Journal of Molecular Liquids"

DOI: 10.1016/j.molliq.2017.11.033

Abstract: Abstract A novel ACE-inhibitory tripeptide Gly-Glu-Phe (GEF) was used to study the molecular mechanism of interactions with ACE. Molecular docking and molecular dynamics simulations were performed to investigate the interactions between GEF and ACE of… read more here.

Keywords: inhibitory tripeptide; mechanism; gef; aqueous solutions ... See more keywords
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Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09283-x

Abstract: During infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for the control of host defense. Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required for the phosphorylation of IRF5… read more here.

Keywords: irf5; gef; recognition; activation irf5 ... See more keywords
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Gefäßnotfälle im Notarztdienst – Teil 1: akute Extremitätenischämie und Gefäßverletzung

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recommendations! Published in 2018 at "Notarzt"

DOI: 10.1055/a-0560-5024

Abstract: Der Beitrag stellt die diagnostischen sowie leitlinienkonforme therapeutische Sofortmasnahmen bei Extremitatenischamie und Gefasverletzungen vor und geht kurz auf die sich innerklinisch anschliesende Therapie ein, um in der Praxis schneller eine Entscheidung treffen zu konnen, uber… read more here.

Keywords: teil akute; gef; lle notarztdienst; gef notf ... See more keywords

Retinale Gefäßverschlüsse als Ausdruck eines generalisierten Gefäßleidens

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recommendations! Published in 2023 at "Klinische Monatsblatter fur Augenheilkunde"

DOI: 10.1055/a-2097-0938

Abstract: Retinale Gefäßverschlüsse stellen nicht nur für das Sehvermögen eine Bedrohung dar, sondern gehen auch mit weiteren systemischen Risikofaktoren und vaskulären Erkrankungen einher. Die interdisziplinäre Zusammenarbeit ist bei diesen Erkrankungen von großer Bedeutung. Dabei unterscheiden sich… read more here.

Keywords: gef; retinale gef; verschl; gef verschl ... See more keywords
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Quaternary organization of the human eEF1B complex reveals unique multi-GEF domain assembly

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac685

Abstract: Abstract Protein synthesis in eukaryotic cell is spatially and structurally compartmentalized that ensures high efficiency of this process. One of the distinctive features of higher eukaryotes is the existence of stable multi-protein complexes of aminoacyl-tRNA… read more here.

Keywords: gef; eef1b; multi; organization human ... See more keywords
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Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

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recommendations! Published in 2022 at "PLOS ONE"

DOI: 10.1101/2022.10.14.508903

Abstract: Obscurin is a giant muscle protein (>800 kDa) featuring multiple signalling domains, including an SH3-DH-PH domain triplet from the Trio-subfamily of guanosine nucleotide exchange factors (GEFs). While previous research suggests that these domains can activate… read more here.

Keywords: gef domains; gef; nucleotide exchange; obscurin gef ... See more keywords