PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202448
Abstract: The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the exchange of GDP for GTP on RAS. However, regulation of the GEF activity remains elusive. Here, the authors report that PPDPF functions as an important regulator… read more here.
Keywords: sos1; ductal adenocarcinoma; ppdpf; gef activity ... See more keywords
Biochemical insight into novel Rab-GEF activity of the mammalian TRAPPIII complex.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167145
Abstract: Transport Protein Particle complexes (TRAPP) are evolutionarily conserved regulators of membrane trafficking, with this mediated by their guanine nucleotide exchange factor (GEF) activity towards Rab GTPases. In metazoans evidence suggests that two different TRAPP complexes… read more here.
Keywords: trappiii complex; trappii; activity; gef activity ... See more keywords
Scaffold-mediated gating of Cdc42 signalling flux
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DOI: 10.7554/elife.25257
Abstract: Scaffold proteins modulate signalling pathway activity spatially and temporally. In budding yeast, the scaffold Bem1 contributes to polarity axis establishment by regulating the GTPase Cdc42. Although different models have been proposed for Bem1 function, there… read more here.
Keywords: cdc42; signalling flux; scaffold mediated; gef activity ... See more keywords