Delivery of gefitinib in synergism with thymoquinone via transferrin-conjugated nanoparticle sensitizes gefitinib-resistant non-small cell lung carcinoma to control metastasis and stemness.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm01148k
Abstract: Epidermal growth factor receptor (EGFR) normally over-expresses in non-small cell lung cancer (NSCLC) cells. Its mutations act as oncogenic drivers in the cellular signal transduction pathway, and induce the downstream activation of numerous key cellular… read more here.
Keywords: a549 cells; a549; resistance; cell ... See more keywords
Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF-κB Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1912368
Abstract: Trilobatin is a common type of flavonoids compounds derived from Lithocarpus polystachyus Rehd leaves. Previous report suggests that trilobatin was potentially involved in pro-and anticancer, antioxidative and anti-hyperglycemic activities. Here, we investigated the anticancer efficiency… read more here.
Keywords: lung cancer; resistant lung; cancer cells; cancer ... See more keywords
Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/1367938
Abstract: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI, such as gefitinib) in lung cancer continues to be a major problem. Recent studies have shown the promise of ferroptosis-inducing therapy in EGFR-TKI resistant… read more here.
Keywords: gefitinib resistant; lung cancer; ferroptosis; gefitinib ... See more keywords
Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0836-8
Abstract: BackgroundLung cancer is one of the most common and deadly tumors around the world. Targeted therapy for patients with certain mutations, especially by use of tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR),… read more here.
Keywords: cell cycle; pc9gr; cancer; cell ... See more keywords