Elucidating the Neuroprotective Mechanism of Geissoschizine Methyl Ether against Parkinson’s Disease: Inhibition of Ferroptosis Pathway via Network Pharmacology and In Vitro Validation
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c06460
Abstract: Geissoschizine methyl ether(GME) is an indole alkaloid isolated from Uncariae Ramulus Cum Uncis, known for its various biological activities, including antioxidant effects, and neuroprotective properties. However, it has not yet been confirmed whether Geissoschizine methyl… read more here.
Keywords: methyl ether; geissoschizine methyl; network pharmacology; pharmacology ... See more keywords
Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook
Sign Up to like & getrecommendations! Published in 2018 at "Current Medicinal Chemistry"
DOI: 10.2174/0929867324666170320114713
Abstract: Background: Geissoschizine methyl ether (GM) is one of the indole alkaloids in Uncaria hook, and an active ingredient of yokukansan (YKS) that improves behavioral and psychological symp-toms of dementia (BPSD) in patients with several types… read more here.
Keywords: geissoschizine methyl; receptor subtypes; serotonin receptor; receptor ... See more keywords