In Vitro Interaction of Geldanamycin with Triazoles and Echinocandins Against Common and Emerging Candida Species
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DOI: 10.1007/s11046-019-00370-7
Abstract: The aim of this study was to determine the in vitro interactions of geldanamycin (Hsp90-inhibitor) with triazoles and echinocandins against common and emerging Candida species. Twenty clinically important Candida strains comprising C. auris, C. albicans,… read more here.
Keywords: range; parapsilosis; triazoles echinocandins; geldanamycin ... See more keywords
Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin
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DOI: 10.1038/s41598-017-18061-y
Abstract: Fibronectin is an extracellular matrix glycoprotein with key roles in cell adhesion and migration. Hsp90 binds directly to fibronectin and Hsp90 depletion regulates fibronectin matrix stability. Where inhibition of Hsp90 with a C-terminal inhibitor, novobiocin,… read more here.
Keywords: stress responsive; response; fibronectin stress; fibronectin ... See more keywords
Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745
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DOI: 10.1080/14786419.2016.1263854
Abstract: Abstract The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM).… read more here.
Keywords: production demethyl; ansamycin polyketide; geldanamycin; demethyl geldanamycin ... See more keywords
Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods
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DOI: 10.12688/f1000research.20844.2
Abstract: Background: Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target. Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the… read more here.
Keywords: geldanamycin; geldanamycin analogues; interaction; active site ... See more keywords
Characterization of Gel16 as a Cytochrome P450 in Geldanamycin Biosynthesis and in-silico Analysis for an Endogenous Electron Transport System.
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DOI: 10.4014/jmb.1809.09008
Abstract: Geldanamycin and its derivatives, inhibitors of heat shock protein 90, are considered potent anticancer drugs, although their biosynthetic pathways have not yet been fully elucidated. The key step of conversion of 4,5-dihydrogeldanamycin to geldanamycin was… read more here.
Keywords: cytochrome p450; geldanamycin; redox partners; characterization gel16 ... See more keywords