Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods
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DOI: 10.12688/f1000research.20844.2
Abstract: Background: Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target. Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the… read more here.
Keywords: geldanamycin; geldanamycin analogues; interaction; active site ... See more keywords