CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.
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DOI: 10.1002/jat.3813
Abstract: Gelsemium elegans Benth., a well‐known toxic herbal plant, is widely used to treat rheumatic arthritis, inflammation and other diseases. Gelsemium contains humantenmine (HMT), which is an important bioactive and toxic alkaloid. Cytochrome P450 enzymes (CYPs)… read more here.
Keywords: detoxification; gelsemium elegans; hmt; toxic alkaloid ... See more keywords
The qualitative and quantitative analyses of Gelsemium elegans.
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DOI: 10.1016/j.jpba.2019.05.015
Abstract: Gelsemium elegans is a traditional Chinese medicine that has been used to treat eczema, bruises, rheumatoid arthritis and skin ulcers for many years, and alkaloids are its major active and toxic constituents. This study aimed… read more here.
Keywords: plant parts; analysis; different plant; gelsemium elegans ... See more keywords
Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity
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DOI: 10.3390/metabo13020195
Abstract: Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium. However, the toxic… read more here.
Keywords: humantenirine; network; pharmacology; excitotoxicity ... See more keywords