CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3813
Abstract: Gelsemium elegans Benth., a well‐known toxic herbal plant, is widely used to treat rheumatic arthritis, inflammation and other diseases. Gelsemium contains humantenmine (HMT), which is an important bioactive and toxic alkaloid. Cytochrome P450 enzymes (CYPs)… read more here.
Keywords: detoxification; gelsemium elegans; hmt; toxic alkaloid ... See more keywords
A New Nonglycosidic Iridoid from Aerial Parts of Gelsemium elegans
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-019-02665-z
Abstract: A new nonglycosidic iridoid, geleganoid G (1), together with six previously reported analogues (2–7), were isolated from the aqueous ethanol extract of the aerial parts of Gelsemium elegans. Their structures were elucidated on the basis… read more here.
Keywords: nonglycosidic iridoid; parts gelsemium; gelsemium elegans; aerial parts ... See more keywords
The qualitative and quantitative analyses of Gelsemium elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.05.015
Abstract: Gelsemium elegans is a traditional Chinese medicine that has been used to treat eczema, bruises, rheumatoid arthritis and skin ulcers for many years, and alkaloids are its major active and toxic constituents. This study aimed… read more here.
Keywords: plant parts; analysis; different plant; gelsemium elegans ... See more keywords
Indole alkaloids from Gelsemium elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.03.016
Abstract: Five previously undescribed monoterpenoid indole alkaloids were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated by HRESIMS, X-ray diffraction, ECD spectra, and molecular modeling. 19,20-Epoxyhumantenine is a humantenine-type alkaloid… read more here.
Keywords: alkaloid; gelsemium elegans; alkaloids gelsemium; indole alkaloids ... See more keywords
Antimicrobial indole alkaloids with adductive C9 aromatic unit from Gelsemium elegans
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.04.041
Abstract: Abstract Gelselegandines A-C (1–3), three unprecedented gelsedines incorporating additional C9 aromatic unit as side chain, were isolated from Gelsemium elegans. Their structures were elucidated by means of spectroscopic techniques and electronic circular dichroism (ECD) calculation.… read more here.
Keywords: aromatic unit; gelsemium elegans; antimicrobial indole; indole alkaloids ... See more keywords
Gelstriamine A, a Triamino Monoterpene Indole Alkaloid with a Caged 6/5/7/6/6/5 Scaffold and Analgesic Alkaloids from Gelsemium elegans Stems.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00062
Abstract: A novel triamino monoterpene indole alkaloid with an unprecedented skeleton, gelstriamine A (1), four new monoterpene indole alkaloids (2-5), and 12 known analogues (6-17) were isolated from Gelsemium elegans. The structures of 1-5 were established… read more here.
Keywords: monoterpene indole; triamino monoterpene; gelsemium elegans; indole alkaloid ... See more keywords
Gelsekoumidines A and B: Two Pairs of Atropisomeric Bisindole Alkaloids from the Roots of Gelsemium elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02463
Abstract: Two pairs of atropisomeric bisindole alkaloids, gelsekoumidines A (1) and B (2), with a new carbon skeleton, were isolated from the roots of Gelsemium elegans. Compounds 1 and 2 represent the first examples of seco-koumine-gelsedine… read more here.
Keywords: roots gelsemium; atropisomeric bisindole; bisindole alkaloids; two pairs ... See more keywords
The multicomponent residue depletion of Gelsemium elegans in pig tissues, urine, and plasma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.1111782
Abstract: Introduction Gelsemium elegans (G. elegans) as a traditional medicinal plant used in livestock production. The use of G. elegans in veterinary clinics may pose safety risks to human health. Objectives The aim of this study… read more here.
Keywords: pig tissues; residue depletion; gelsemium elegans; depletion ... See more keywords
Sex Differences in the In Vivo Exposure Process of Multiple Components of Gelsemium elegans in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo13010033
Abstract: Asian Gelsemium elegans (G. elegans) has a wide range of pharmacological activities. However, its strong toxicity limits its potential development and application. Interestingly, there are significant gender differences in G. elegans toxicity in rats. This… read more here.
Keywords: gelsemium elegans; toxicity; elegans rats; process ... See more keywords
Structural Elucidation and Cytotoxic Activity of New Monoterpenoid Indoles from Gelsemium elegans
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062531
Abstract: Two new monoterpenoid indole alkaloids, gelselegandines F (1) and G (2), were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. The ECD… read more here.
Keywords: cytotoxic activity; new monoterpenoid; gelsemium elegans; structural elucidation ... See more keywords