Tropomyosins Regulate the Severing Activity of Gelsolin in Isoform-Dependent and Independent Manners
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.3812
Abstract: The actin cytoskeleton fulfills numerous key cellular functions, which are tightly regulated in activity, localization, and temporal patterning by actin binding proteins. Tropomyosins and gelsolin are two such filament-regulating proteins. Here, we investigate how the… read more here.
Keywords: activity gelsolin; tropomyosin isoforms; gelsolin; actin filaments ... See more keywords
Antagonistic sepsis markers: Serum gelsolin and actin/gelsolin ratio.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2016.10.018
Abstract: OBJECTIVES For appropriate sepsis care, prognostic laboratory markers are mandatory. The aim of our study was to evaluate the predictive value of serum actin, gelsolin and the recently defined actin/gelsolin ratio during sepsis by comparison… read more here.
Keywords: sepsis; gelsolin actin; gelsolin; gelsolin ratio ... See more keywords
AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx056
Abstract: Gelsolin amyloidosis is a dominantly inherited, incurable type of amyloidosis. A single point mutation in the gelsolin gene (G654A is most common) results in the loss of a Ca2+ binding site in the second gelsolin… read more here.
Keywords: amyloid burden; gelsolin; bispecific nanobody; amyloidosis ... See more keywords
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2019-0110
Abstract: Abstract Synaptic plasticity underlies central brain functions, such as learning. Ca2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes.… read more here.
Keywords: actin; gelsolin; chemical; ltd ltp ... See more keywords
Gelsolin Attenuates Neonatal Hyperoxia-Induced Inflammatory Responses to Rhinovirus Infection and Preserves Alveolarization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.792716
Abstract: Prematurity and bronchopulmonary dysplasia (BPD) increase the risk of asthma later in life. Supplemental oxygen therapy is a risk factor for chronic respiratory symptoms in infants with BPD. Hyperoxia induces cell injury and release of… read more here.
Keywords: hyperoxia induced; gelsolin; hyperoxic balf; neonatal hyperoxia ... See more keywords
Physical Interaction between HPV16E7 and the Actin-Binding Protein Gelsolin Regulates Epithelial-Mesenchymal Transition via HIPPO-YAP Axis
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13020353
Abstract: Simple Summary Human papilloma viruses cause benign or malignant hyper-proliferative lesions in cervical, anogenital and oropharyngeal tissues. Our previous studies revealed that HPV16 E7 alters actin cytoskeleton mainly by binding to and inhibiting Gelsolin. We… read more here.
Keywords: mesenchymal transition; actin; gelsolin; epithelial mesenchymal ... See more keywords