An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12743
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer‐related deaths in the United States by 2020, due in part to innate resistance to widely used chemotherapeutic agents and limited knowledge… read more here.
Keywords: cancer; drug screen; gem; pdac ... See more keywords
Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800593
Abstract: The low radical surgery rate of pancreatic cancer leads to increased local recurrence and poor prognosis. Gemcitabine (GEM) is the preferred chemotherapeutic for pancreatic cancer. However, systemic chemotherapy with GEM has reached a bottleneck due… read more here.
Keywords: gem; recurrence; delivery; electrospun fibers ... See more keywords
Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413439
Abstract: Extensive fibrous stroma plays an important role in gemcitabine (GEM) resistance. However, the mechanism by which pancreatic cancer cells interact with pancreatic stellate cells (PSCs) to promote GEM resistance remains unclear. This study investigates the… read more here.
Keywords: cancer; linc znf25; gem; cancer cell ... See more keywords
Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2764
Abstract: Gemcitabine (GEM) alone and GEM‐based chemotherapy are the preferred regimens for treating advanced unresectable and metastatic pancreatic cancer (PC). However, these treatments have limited efficacy due to acquired resistance of cancer cells to chemotherapy, the… read more here.
Keywords: gem; cell lines; pancreatic cancer; resistant cell ... See more keywords
A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900324
Abstract: The main concern in the use of anticancer chemotherapeutic drugs is host toxicity. Patients need to interrupt or change chemotherapy due to adverse effects. In this study, we aimed to decrease adverse events with gemcitabine… read more here.
Keywords: gem; hydrogen peroxide; treatment; pancreatic ductal ... See more keywords
N‐Directed defluorinative γ‐C(sp3)−H allylation of sulfamate esters for synthesis of gem‐difluoroalkenes via photoredox catalysis
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400011
Abstract: gem‐Difluoroalkenes are unique structural motifs with important applications ranging from drugs to materials. Herein, we report a novel radical‐mediated defluorinative allylation of sulfamate esters with α‐trifluoromethyl alkenes through distal C(sp3)−H functionalization under photoredox conditions. The reaction… read more here.
Keywords: sp3; gem difluoroalkenes; allylation sulfamate; gem ... See more keywords
Synthesis of 2H‐1,2‐oxazin‐3(6H)‐one via the Cycloaddition of Nitrosobenzene with Gem‐difluoro‐1,3‐diene
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500289
Abstract: An efficient access to 2H‐1,2‐oxazin‐3(6H)‐one via the nitro‐Diels‐Alder reactions of nitrobenzene with gem‐difluoro‐1,3‐diene is developed under mild reaction conditions. This strategy features good functional group tolerance, good to high yields and free of catalyst. The… read more here.
Keywords: one via; oxazin one; gem; gem difluoro ... See more keywords
Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27421
Abstract: Ovarian cancer is the major cause of death in women gynecological malignancy and gemcitabine (GEM) is commonly used in related chemotherapy. However, more than 90% GEM is catalyzed into an inactive metabolite 2′‐deoxy‐2′,2′‐difluorouridine by stromal… read more here.
Keywords: reactive oxygen; gem; oxygen species; dha ... See more keywords
Synthesis of Selectively gem-Difluorinated Molecules; Chiral gem-Difluorocyclopropanes via Chemo-Enzymatic Reaction and gem-Difluorinated Compounds via Radical Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300028
Abstract: The incorporation of fluorine atoms into an organic compound can alter the chemical reactivity or biological activity of the resulting compound due to the strong electron withdrawing nature of the fluorine atom. We have synthesized… read more here.
Keywords: gem difluorocyclopropanes; gem difluorinated; gem; reaction ... See more keywords
Gaseous Elemental Mercury (GEM) in the Mexico City Metropolitan Area
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-021-03293-6
Abstract: This paper presents atmospheric gaseous elemental mercury (GEM) data recorded during two short-term monitoring surveys in the Mexico City Metropolitan Area (MCMA) at 12th May 2019 and at 22nd May 2020, during conditions of low… read more here.
Keywords: gaseous elemental; gem; mexico city; mercury gem ... See more keywords
Combination chemotherapy for older patients with unresectable biliary tract cancer: a prospective observational study using propensity-score matched analysis (JON2104-B)
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-025-02294-0
Abstract: Systemic chemotherapy with gemcitabine plus S-1 (GEM + S-1), GEM + CDDP plus S-1 (GEM + CDDP + S-1), or gemcitabine plus cisplatin (GEM + CDDP) is standard treatment for advanced biliary tract cancer (aBTC). We aimed to evaluate the efficacy and safety of combination… read more here.
Keywords: gemcitabine; chemotherapy; older patients; gem ... See more keywords