An unbiased high‐throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12743
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer‐related deaths in the United States by 2020, due in part to innate resistance to widely used chemotherapeutic agents and limited knowledge… read more here.
Keywords: cancer; drug screen; gem; pdac ... See more keywords
Localized Controlled Delivery of Gemcitabine via Microsol Electrospun Fibers to Prevent Pancreatic Cancer Recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800593
Abstract: The low radical surgery rate of pancreatic cancer leads to increased local recurrence and poor prognosis. Gemcitabine (GEM) is the preferred chemotherapeutic for pancreatic cancer. However, systemic chemotherapy with GEM has reached a bottleneck due… read more here.
Keywords: gem; recurrence; delivery; electrospun fibers ... See more keywords
Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2764
Abstract: Gemcitabine (GEM) alone and GEM‐based chemotherapy are the preferred regimens for treating advanced unresectable and metastatic pancreatic cancer (PC). However, these treatments have limited efficacy due to acquired resistance of cancer cells to chemotherapy, the… read more here.
Keywords: gem; cell lines; pancreatic cancer; resistant cell ... See more keywords
A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900324
Abstract: The main concern in the use of anticancer chemotherapeutic drugs is host toxicity. Patients need to interrupt or change chemotherapy due to adverse effects. In this study, we aimed to decrease adverse events with gemcitabine… read more here.
Keywords: gem; hydrogen peroxide; treatment; pancreatic ductal ... See more keywords
Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27421
Abstract: Ovarian cancer is the major cause of death in women gynecological malignancy and gemcitabine (GEM) is commonly used in related chemotherapy. However, more than 90% GEM is catalyzed into an inactive metabolite 2′‐deoxy‐2′,2′‐difluorouridine by stromal… read more here.
Keywords: reactive oxygen; gem; oxygen species; dha ... See more keywords
Synthesis of Selectively gem-Difluorinated Molecules; Chiral gem-Difluorocyclopropanes via Chemo-Enzymatic Reaction and gem-Difluorinated Compounds via Radical Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical record"
DOI: 10.1002/tcr.202300028
Abstract: The incorporation of fluorine atoms into an organic compound can alter the chemical reactivity or biological activity of the resulting compound due to the strong electron withdrawing nature of the fluorine atom. We have synthesized… read more here.
Keywords: gem difluorocyclopropanes; gem difluorinated; gem; reaction ... See more keywords
Gaseous Elemental Mercury (GEM) in the Mexico City Metropolitan Area
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-021-03293-6
Abstract: This paper presents atmospheric gaseous elemental mercury (GEM) data recorded during two short-term monitoring surveys in the Mexico City Metropolitan Area (MCMA) at 12th May 2019 and at 22nd May 2020, during conditions of low… read more here.
Keywords: gaseous elemental; gem; mexico city; mercury gem ... See more keywords
Regional to country-based seismic hazard modeling
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Earthquake Engineering"
DOI: 10.1007/s10518-018-0376-y
Abstract: Seismic risk mitigation and minimizing the loss of human lives as well as social and economic disruption due to earthquakes depend on reliable seismic hazard assessment. Global and local collaborative efforts in this perspective should… read more here.
Keywords: hazard; share; gem; seismic hazard ... See more keywords
Evaluation of possible impact on human health of atmospheric mercury emanations from the Popocatépetl volcano
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Geochemistry and Health"
DOI: 10.1007/s10653-020-00610-6
Abstract: The contribution of Hg from volcanic emanations is decisive for assessing global mercury emissions given the impact of this highly toxic contaminant on human health and ecosystems. Atmospheric Hg emissions from Popocatépetl volcano and their… read more here.
Keywords: popocat petl; gem; volcano; human health ... See more keywords
Indoor and outdoor elemental mercury: a comparison of three different cases
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Monitoring and Assessment"
DOI: 10.1007/s10661-017-5781-1
Abstract: Gaseous elemental mercury (GEM) concentrations were determined in three different indoor environments: an office in a building with no indoor sources of mercury (Bldg. I), an office affected by indoor mercury emissions from an adjacent… read more here.
Keywords: indoor gem; gem; elemental mercury; lower upper ... See more keywords
Improving Plasma Stability and Bioavailability In Vivo of Gemcitabine Via Nanoparticles of mPEG-PLG-GEM Complexed with Calcium Phosphate
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2506-2
Abstract: PurposeDespite being widely used for the treatment of several solid tumors, Gemcitabine (GEM) exhibits several suboptimal pharmacokinetic properties. Therefore, the design of nanoparticle delivery systems is a promising strategy to enhance GEM pharmacokinetic properties.MethodsIn this… read more here.
Keywords: calcium; mpeg plg; gem; plg gem ... See more keywords