Regulation of geminin by neuropeptide Y in vascular smooth muscle cell proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Herz"
DOI: 10.1007/s00059-018-4721-3
Abstract: Geminin, a key regulator of DNA replication licensing in the cell cycle, plays an essential role in determining the fate of cells via suppression of cell proliferation and cellular differentiation. Neuropeptide Y (NPY) intensifies the proliferation of vascular… read more here.
Keywords: vascular smooth; geminin; proliferation; der ... See more keywords
Clinicopathologic significance of DNA replication licensing factors in head and neck diffuse large B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2021 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2021.10.018
Abstract: OBJECTIVE Diffuse large B-cell lymphoma (DLBCL) harbors defects in the proliferation pathway. We performed multiparameter analysis of proteins expressed during different cell cycle phases and correlated them with clinical parameters of head and neck DLBCLs.… read more here.
Keywords: cell lymphoma; mcm2; geminin; cell ... See more keywords
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.21
Abstract: Correct control of DNA replication is crucial to maintain genomic stability in dividing cells. Inappropriate re-licensing of replicated origins is associated with chromosomal instability (CIN), a hallmark of cancer progression that at the same time… read more here.
Keywords: replication; breast cancer; geminin; dub3 usp7 ... See more keywords
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00311-x
Abstract: Triple-negative breast cancer (TNBCs) display lung metastasis tropism. However, the mechanisms underlying this organ-specific pattern remains to be elucidated. We sought to evaluate the utility of blocking extravasation to prevent lung metastasis. To identify potential… read more here.
Keywords: tnbc; geminin; lung metastasis; geminin overexpressing ... See more keywords
Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55702-w
Abstract: Dissemination of metastatic precursors from primaries is the primary reason for patient death. Dissemination encompasses tumor cells invasion of stroma, followed by intravasation through the endothelium barrier into the bloodstream. Here, we describe how geminin-overexpressing… read more here.
Keywords: geminin overexpression; geminin; geminin overexpressing; rage ... See more keywords
The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0020
Abstract: DNA re-replication leads to genomic instability and has been implicated in the pathology of a variety of human cancers. Eukaryotic DNA replication is tightly controlled to ensure it occurs only once during each cell cycle.… read more here.
Keywords: replication; dna replication; cdk2; geminin ... See more keywords
Tumor size and proliferative marker geminin rather than Ki67 expression levels significantly associated with maximum uptake of 18F-deoxyglucose levels on positron emission tomography for breast cancers
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184508
Abstract: It has been well established that maximum standardized uptake value (SUVmax) for 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) is clinically useful for evaluating treatment efficacy as well as predicting prognosis of breast cancer patients. Although… read more here.
Keywords: breast; expression levels; geminin; breast cancers ... See more keywords
Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1046269
Abstract: Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhances reactive oxygen species (ROS)… read more here.
Keywords: geminin; high grade; lysophosphatidic acid; ovarian cancer ... See more keywords
Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.860682
Abstract: DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication… read more here.
Keywords: geminin; cdt1 geminin; replication; geminin protein ... See more keywords