The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00311-x
Abstract: Triple-negative breast cancer (TNBCs) display lung metastasis tropism. However, the mechanisms underlying this organ-specific pattern remains to be elucidated. We sought to evaluate the utility of blocking extravasation to prevent lung metastasis. To identify potential… read more here.
Keywords: tnbc; geminin; lung metastasis; geminin overexpressing ... See more keywords
Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55702-w
Abstract: Dissemination of metastatic precursors from primaries is the primary reason for patient death. Dissemination encompasses tumor cells invasion of stroma, followed by intravasation through the endothelium barrier into the bloodstream. Here, we describe how geminin-overexpressing… read more here.
Keywords: geminin overexpression; geminin; geminin overexpressing; rage ... See more keywords