Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins
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DOI: 10.1091/mbc.e16-12-0855
Abstract: The ESCRT-I protein TSG101 can mitigate endoplasmic reticulum stress–mediated apoptosis involving caspase 4/12 caused by MGRN1 depletion, probably contributing to neurodegeneration. TSG101 associates with ALIX to prevent predisposition to apoptosis, whereas ALIX–ALG-2 interaction favors a… read more here.
Keywords: 101 regulates; apoptosis; gene 101; tumor susceptibility ... See more keywords
Neuronal Deletion of Tumor Susceptibility Gene 101 (Tsg101) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons
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DOI: 10.3390/biom15060786
Abstract: Endosomal dysfunction is one of the earliest cellular signs in Alzheimer’s disease. Tumor susceptibility gene 101 protein (TSG101) is a component of the endosomal sorting complex required for transport (ESCRT)-I, which plays a key role… read more here.
Keywords: gene 101; hippocampal ca3; tumor susceptibility; gene ... See more keywords
The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease
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DOI: 10.3390/cancers12020450
Abstract: The multidomain protein encoded by the Tumor Susceptibility Gene 101 (TSG101) is ubiquitously expressed and is suggested to function in diverse intracellular processes. In this review, we provide a succinct overview of the main structural… read more here.
Keywords: 101 tsg101; susceptibility gene; tsg101; gene 101 ... See more keywords