Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations
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DOI: 10.1002/advs.202105853
Abstract: Well‐preserved molecular cargo in circulating extracellular vesicles (EVs) offers an ideal material for detecting oncogenic gene alterations in cancer patients, providing a noninvasive diagnostic solution for detection of disease status and monitoring treatment response. Therefore,… read more here.
Keywords: lipid labeling; extracellular vesicles; chemistry; oncogenic gene ... See more keywords
Germline and somatic DNA repair gene alterations in prostate cancer
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DOI: 10.1002/cncr.32908
Abstract: Emerging evidence has suggested that DNA repair gene alterations may be important in prostate cancer pathogenesis. In the current study, the authors sought to characterize alterations in DNA repair pathway genes in both primary and… read more here.
Keywords: dna repair; gene alterations; prostate cancer; repair gene ... See more keywords
TRPS1 gene alterations in human subependymoma
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DOI: 10.1007/s11060-017-2496-7
Abstract: Subependymoma is a rare primary brain tumor, constituting 0.07–0.51% of brain tumors. Genetic alterations in subependymoma are largely unknown, but familial occurrences have been reported. Trichorhinophalangeal syndrome type 1 (TRPS1) is a rare hereditary malformation… read more here.
Keywords: gene alterations; trps1 gene; subependymoma; tumor ... See more keywords
Breast cancer and DDT: putative interactions, associated gene alterations, and molecular pathways
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-12489-6
Abstract: The global burden of cancer has recorded an ever-increasing trend in the developing world. The GLOBOCAN, 2018 report has ranked breast cancer (BC) as the second (11.6%) most common form of cancer afflicting the female… read more here.
Keywords: gene alterations; breast cancer; ddt; cancer ... See more keywords
Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer
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DOI: 10.1038/s41591-023-02791-w
Abstract: Certain genetic alterations and right-sided primary tumor location are associated with resistance to anti-epidermal growth factor (EGFR) treatment in metastatic colorectal cancer (mCRC). The phase 3 PARADIGM trial (n = 802) demonstrated longer overall survival with first-line… read more here.
Keywords: colorectal cancer; metastatic colorectal; gene alterations; gene ... See more keywords
Gene alterations and epigenetic changes in intrahepatic cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2017.1266261
Abstract: ABSTRACT Introduction: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm. The incidence of ICC has been increasing world-wide over the past several decades. Areas covered: The pathogenesis of ICC is a complex process involving the… read more here.
Keywords: alterations epigenetic; intrahepatic cholangiocarcinoma; gene alterations; icc ... See more keywords
Relationship between plasminogen activator inhibitor‐1 gene alterations and fibrosis in peritoneal dialysis patients
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.13501
Abstract: Peritoneal fibrosis (PF) is a pathological change that occurs mostly long‐term peritoneal dialysis (PD) patients, as a result of triggering the inflammatory response. Plasminogen activator inhibitor‐1 (PAI‐1) is an important molecule featured in the development… read more here.
Keywords: plasminogen activator; gene alterations; peritoneal dialysis; dialysis patients ... See more keywords
Clinical significance of CD28 gene‐related activating alterations in adult T‐cell leukaemia/lymphoma
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DOI: 10.1111/bjh.17211
Abstract: Multiple oncogenic events are involved in the development of adult T‐cell leukaemia/lymphoma (ATL). Because CD28 plays a pivotal role in T‐cell activation, we focused on alterations of the CD28 gene in ATL. We found multiple… read more here.
Keywords: gene; cd28 gene; gene alterations; adult cell ... See more keywords
Characterizations of Gene Alterations in Melanoma Patients from Chinese Population
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DOI: 10.1155/2020/6096814
Abstract: Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection. We conducted comprehensive genomic profiling… read more here.
Keywords: melanomas; alterations melanoma; characterizations gene; gene alterations ... See more keywords
Abstract 3399: Real-world experience of the clinical correlation between ARID gene alterations /RNA expression levels and treatment benefit of immunotherapy in malignant solid tumors
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DOI: 10.1158/1538-7445.am2025-3399
Abstract: Cancer immunotherapies provide durable benefits for many, but not all patients with various types of solid tumor. Accumulating research suggests that patients with ARID gene alterations of the human switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex are… read more here.
Keywords: rna expression; cancer; patients cohort; arid gene ... See more keywords
BCOR gene alterations in hematological diseases.
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DOI: 10.1182/blood.2021010958
Abstract: The BCL6 co-repressor (BCOR) is a transcription factor involved in the control of embryogenesis, mesenchymal stem cells function, hematopoiesis and lymphoid development. Recurrent somatic clonal mutations of the BCOR gene and its homologue BCORL1 have… read more here.
Keywords: bcor gene; gene alterations; bcor; alterations hematological ... See more keywords