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   Articles with "gene amplification" as a keyword



Plasmon‐Driven Gold Nanopillar Multiarrayed Gene Amplification Methodology for the High‐Throughput Discrimination of Pathogens

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202411849

Abstract: Molecular diagnosis limitations, including complex treatment processes, low cost‐effectiveness, and operator‐dependent low reproducibility, interrupt the timely prevention of disease spread and the development of medical devices for home and outdoor uses. A newly fabricated gold… read more here.

Keywords: gene amplification; high throughput; methodology; gold nanopillar ... See more keywords

Diversification of the calponin family proteins by gene amplification and repeat expansion of calponin‐like motifs

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recommendations! Published in 2021 at "Cytoskeleton"

DOI: 10.1002/cm.21683

Abstract: The calponin family proteins in vertebrates, including calponin and transgelin (also known as SM22 or NP25), regulate actin‐myosin interaction and actin filament stability and are involved in regulation of muscle contractility and cell migration. Related… read more here.

Keywords: amplification repeat; calponin family; family proteins; gene amplification ... See more keywords

Herbicide-resistance mechanisms: gene amplification is not just for glyphosate.

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recommendations! Published in 2017 at "Pest management science"

DOI: 10.1002/ps.4679

Abstract: During the past decade, one of the most novel findings emerging from herbicide-resistance research was gene amplification as a resistance mechanism. Although amplification of genes— including genes encoding detoxifying enzymes as well as genes encoding… read more here.

Keywords: herbicide resistance; gene amplification; resistance; amplification ... See more keywords
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No pains, no gains: how chromosome fragmentation promotes gene amplification.

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recommendations! Published in 2021 at "Molecular cell"

DOI: 10.1016/j.molcel.2021.02.018

Abstract: Combining live-cell imaging, cytogenetics, genome sequencing, and in vitro evolution, Shoshani et al. (2020) revealed deep connections between chromothripsis, the catastrophic shattering of a chromosome in abnormal nuclear structures, and gene amplification, a frequent culprit of oncogenic… read more here.

Keywords: chromosome fragmentation; gains chromosome; pains gains; gene ... See more keywords

Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic implications

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recommendations! Published in 2017 at "Modern Pathology"

DOI: 10.1038/modpathol.2016.202

Abstract: Cancer cells use PD-L1 to evade antitumor immunity through interaction with programmed cell death protein 1 (PD-1) on T cells. Recent whole-genome sequence studies revealed frequent gene amplification of PD-L1 in Epstein–Barr virus-associated gastric cancer… read more here.

Keywords: cancer; expression; gene amplification; cancer cells ... See more keywords
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A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases

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recommendations! Published in 2020 at "Modern Pathology"

DOI: 10.1038/s41379-020-00664-y

Abstract: PD-L1 immunohistochemistry (IHC) currently has the most Food and Drug Administration (FDA) approvals as a companion diagnostic (CDx) for immunotherapies in specific tumor types; however, multiple other immunotherapy biomarkers exist. We performed this study to… read more here.

Keywords: tmb; analysis; gene amplification; tumor ... See more keywords
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TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer

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recommendations! Published in 2021 at "NPJ Breast Cancer"

DOI: 10.1038/s41523-021-00250-8

Abstract: Metaplastic breast cancers (MBCs) are characterized by complex genomes, which seem to vary according to their histologic subtype. TERT promoter hotspot mutations and gene amplification are rare in common forms of breast cancer, but present… read more here.

Keywords: hotspot mutations; tert promoter; promoter; promoter hotspot ... See more keywords

CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep41431

Abstract: Over-expression of a gene by increasing its copy number is often desirable in the model yeast Saccharomyces cerevisiae. It may facilitate elucidation of enzyme functions, and in cell factory design it is used to increase… read more here.

Keywords: selection free; gene expression; expression; gene ... See more keywords

Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2112608119

Abstract: Significance The Mycobacterium tuberculosis (Mtb) ESX-3 type VII secretion system plays a critical role in iron acquisition. Infection of mice with highly attenuated Mtb deletion mutants lacking esxG or esxH, genes encoding key ESX-3 substrates,… read more here.

Keywords: mycobacterium tuberculosis; secretion; esx; gene amplification ... See more keywords

B-cell ALL with SOX11 gene amplification associates with a worse outcome

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recommendations! Published in 2024 at "Cell Cycle"

DOI: 10.1080/15384101.2024.2306756

Abstract: ABSTRACT Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using… read more here.

Keywords: cell; cell sox11; sox11 gene; amplification associates ... See more keywords

Human epidermal growth factor receptor 2 (HER2) gene amplification in non-muscle invasive urothelial bladder cancers: Identification of patients for targeted therapy

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recommendations! Published in 2020 at "Arab Journal of Urology"

DOI: 10.1080/2090598x.2020.1814183

Abstract: ABSTRACT Objectives To evaluate human epidermal growth factor receptor 2 (HER2) protein overexpression by immunohistochemistry (IHC) and gene amplification by fluorescent in situ hybridisation (FISH) in urothelial non-muscle-invasive bladder carcinoma (NMIBC), as HER2 is a… read more here.

Keywords: grade; amplification; her2; bladder ... See more keywords