Diversification of the calponin family proteins by gene amplification and repeat expansion of calponin‐like motifs
Sign Up to like & getrecommendations! Published in 2021 at "Cytoskeleton"
DOI: 10.1002/cm.21683
Abstract: The calponin family proteins in vertebrates, including calponin and transgelin (also known as SM22 or NP25), regulate actin‐myosin interaction and actin filament stability and are involved in regulation of muscle contractility and cell migration. Related… read more here.
Keywords: amplification repeat; calponin family; family proteins; gene amplification ... See more keywords
Herbicide-resistance mechanisms: gene amplification is not just for glyphosate.
Sign Up to like & getrecommendations! Published in 2017 at "Pest management science"
DOI: 10.1002/ps.4679
Abstract: During the past decade, one of the most novel findings emerging from herbicide-resistance research was gene amplification as a resistance mechanism. Although amplification of genes— including genes encoding detoxifying enzymes as well as genes encoding… read more here.
Keywords: herbicide resistance; gene amplification; resistance; amplification ... See more keywords
No pains, no gains: how chromosome fragmentation promotes gene amplification.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.02.018
Abstract: Combining live-cell imaging, cytogenetics, genome sequencing, and in vitro evolution, Shoshani et al. (2020) revealed deep connections between chromothripsis, the catastrophic shattering of a chromosome in abnormal nuclear structures, and gene amplification, a frequent culprit of oncogenic… read more here.
Keywords: chromosome fragmentation; gains chromosome; pains gains; gene ... See more keywords
Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic implications
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.202
Abstract: Cancer cells use PD-L1 to evade antitumor immunity through interaction with programmed cell death protein 1 (PD-1) on T cells. Recent whole-genome sequence studies revealed frequent gene amplification of PD-L1 in Epstein–Barr virus-associated gastric cancer… read more here.
Keywords: cancer; expression; gene amplification; cancer cells ... See more keywords
A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-00664-y
Abstract: PD-L1 immunohistochemistry (IHC) currently has the most Food and Drug Administration (FDA) approvals as a companion diagnostic (CDx) for immunotherapies in specific tumor types; however, multiple other immunotherapy biomarkers exist. We performed this study to… read more here.
Keywords: tmb; analysis; gene amplification; tumor ... See more keywords
TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-021-00250-8
Abstract: Metaplastic breast cancers (MBCs) are characterized by complex genomes, which seem to vary according to their histologic subtype. TERT promoter hotspot mutations and gene amplification are rare in common forms of breast cancer, but present… read more here.
Keywords: hotspot mutations; tert promoter; promoter; promoter hotspot ... See more keywords
CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41431
Abstract: Over-expression of a gene by increasing its copy number is often desirable in the model yeast Saccharomyces cerevisiae. It may facilitate elucidation of enzyme functions, and in cell factory design it is used to increase… read more here.
Keywords: selection free; gene expression; expression; gene ... See more keywords
Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112608119
Abstract: Significance The Mycobacterium tuberculosis (Mtb) ESX-3 type VII secretion system plays a critical role in iron acquisition. Infection of mice with highly attenuated Mtb deletion mutants lacking esxG or esxH, genes encoding key ESX-3 substrates,… read more here.
Keywords: mycobacterium tuberculosis; secretion; esx; gene amplification ... See more keywords
Human epidermal growth factor receptor 2 (HER2) gene amplification in non-muscle invasive urothelial bladder cancers: Identification of patients for targeted therapy
Sign Up to like & getrecommendations! Published in 2020 at "Arab Journal of Urology"
DOI: 10.1080/2090598x.2020.1814183
Abstract: ABSTRACT Objectives To evaluate human epidermal growth factor receptor 2 (HER2) protein overexpression by immunohistochemistry (IHC) and gene amplification by fluorescent in situ hybridisation (FISH) in urothelial non-muscle-invasive bladder carcinoma (NMIBC), as HER2 is a… read more here.
Keywords: grade; amplification; her2; bladder ... See more keywords
Predicting epidermal growth factor receptor gene amplification status in glioblastoma multiforme by quantitative enhancement and necrosis features deriving from conventional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000010833
Abstract: Abstract To study whether some of the quantitative enhancement and necrosis features in preoperative conventional MRI (cMRI) had a predictive value for epidermal growth factor receptor (EGFR) gene amplification status in glioblastoma multiforme (GBM). Fifty-five… read more here.
Keywords: amplification status; gene; gene amplification; quantitative enhancement ... See more keywords
Prediction of MYCN Gene Amplification in Pediatric Neuroblastomas: Development of a Deep Learning-Based Tool for Automatic Tumor Segmentation and Comparative Analysis of Computed Tomography-Based Radiomics Features Harmonization.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of computer assisted tomography"
DOI: 10.1097/rct.0000000000001480
Abstract: OBJECTIVE MYCN oncogene amplification is closely linked to high-grade neuroblastoma with poor prognosis. Accurate quantification is essential for risk assessment, which guides clinical decision making and disease management. This study proposes an end-to-end deep-learning framework… read more here.
Keywords: mycn gene; tumor segmentation; amplification; tumor ... See more keywords