Gene‐based and pathway‐based testing for rare‐variant association in affected sib pairs
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22291
Abstract: Next generation sequencing technologies have made it possible to investigate the role of rare variants (RVs) in disease etiology. Because RVs associated with disease susceptibility tend to be enriched in families with affected individuals, study… read more here.
Keywords: affected sib; association; gene based; sib pairs ... See more keywords
Emergence of S gene‐based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28167
Abstract: In this study, we collected two subsequent swabs from 7 immunocompetent up to date vaccinated healthcare workers undergoing mild symptomatic SARS-CoV-2 infection, and applied a next generation sequencing approach to establish the intra-host dynamics of… read more here.
Keywords: omicron; immunocompetent; gene based; emergence gene ... See more keywords
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21479
Abstract: Gene‐based therapy is one of essential therapeutic strategies for precision medicine through targeting specific genes in specific cells of target tissues. However, there still exist many problems that need to be solved, such as safety,… read more here.
Keywords: delivery; acid drugs; gene based; based therapy ... See more keywords
Omnibus testing approach for gene‐based gene‐gene interaction
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9389
Abstract: Genetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the… read more here.
Keywords: based gene; interaction; gene gene; gene interaction ... See more keywords
Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2181-5
Abstract: The recruitment of T-cells by bispecific antibodies secreted from adoptively transferred, gene-modified autologous cells has shown satisfactory results in preclinical cancer models. Even so, the approach’s translation into the clinic will require incremental improvements to… read more here.
Keywords: light cell; cell engagers; based immunotherapy; gene based ... See more keywords
Identification of survival-related genes and a novel gene-based prognostic signature involving the tumor microenvironment of uveal melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107816
Abstract: Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults and almost fifty percent of patients subsequently develop systemic metastases usually involving the liver. The tumor microenvironment (TME) is crucial to the… read more here.
Keywords: prognostic signature; based prognostic; gene based; gene ... See more keywords
A computer simulation to investigate the association between gene-based gifting and pair-bonding in early hominins
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Human Evolution"
DOI: 10.1016/j.jhevol.2017.11.009
Abstract: This article describes simulation research based on the Hamiltonian theory of gene-based altruism. It investigates the origin of semipermanent breeding bonds during hominin evolution. The research framework is based on a biologically detailed, ecologically situated,… read more here.
Keywords: research; semipermanent breeding; breeding bonds; gene based ... See more keywords
A rare disease patient/caregiver perspective on fair pricing and access to gene-based therapies
Sign Up to like & getrecommendations! Published in 2019 at "Gene Therapy"
DOI: 10.1038/s41434-019-0110-7
Abstract: Gene-based therapies are changing the landscape of medicine for patients with rare diseases. These one-time, potentially curative treatments pose a challenge in the US healthcare model, where high prices and insurance coverage variation may prevent… read more here.
Keywords: high prices; based therapies; value; gene based ... See more keywords
ExPheWas: a platform for cis-Mendelian randomization and gene-based association scans
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac289
Abstract: Abstract Establishing the relationship between protein-coding genes and phenotypes has the potential to inform on the molecular etiology of diseases. Here, we describe ExPheWas (exphewas.ca), a gene-based phenome-wide association study browser and platform that enables… read more here.
Keywords: based association; mendelian randomization; gene; gene based ... See more keywords
LDAK-GBAT: fast and powerful gene-based association testing using summary statistics
Sign Up to like & getrecommendations! Published in 2022 at "American journal of human genetics"
DOI: 10.1101/2022.07.01.22277161
Abstract: We present LDAK-GBAT, a novel tool for gene-based association testing using summary statistics from genome-wide association studies. We first evaluate LDAK-GBAT using ten phenotypes from the UK Biobank. We show that LDAK-GBAT is computationally efficient,… read more here.
Keywords: based association; association testing; gbat; gene based ... See more keywords
In silico genome-wide gene-based association analysis reveals new genes predisposing to CAD.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical genetics"
DOI: 10.1111/cge.14073
Abstract: Genome-wide association analyses (GWAS) have identified more than 300 single nucleotide polymorphisms at 163 independent loci associated with coronary artery disease (CAD). However, there is no full understanding about the causal genes for CAD and… read more here.
Keywords: analysis; based association; cad; gene based ... See more keywords