Gene body DNA methylation in plants.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2016.12.007
Abstract: The type, amount, and location of DNA methylation within a gene provides pivotal information on the enzymatic pathway by which it was achieved and its functional consequences. In plants (angiosperms specifically), gene body methylation (gbM)… read more here.
Keywords: methylation; gene body; gene; dna methylation ... See more keywords
A novel HER2 gene body enhancer contributes to HER2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.382
Abstract: The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocrine… read more here.
Keywords: her2 gene; her2; gene body; her2 expression ... See more keywords
Gene body demethylation increases expression and is associated with self-pruning during grape genome duplication
Sign Up to like & getrecommendations! Published in 2020 at "Horticulture Research"
DOI: 10.1038/s41438-020-0303-7
Abstract: A colchicine-induced autotetraploid grapevine exhibiting potentially valuable agronomic traits for grape production and breeding, including self-pruning, was identified. This study investigated DNA methylation variation and its role in gene expression during self-pruning in the autotetraploid… read more here.
Keywords: gene body; self pruning; gene expression; expression ... See more keywords
A Broad Survey of Gene Body and Repeat Methylation in Cnidaria Reveals a Complex Evolutionary History
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evab284
Abstract: Abstract DNA methylation, an important component of eukaryotic epigenetics, varies in pattern and function across Metazoa. Notably, bilaterian vertebrates and invertebrates differ dramatically in gene body methylation (GbM). Using the frequency of cytosine-phospho-guanines (CpGs), which… read more here.
Keywords: methylation; gene body; broad survey; methylation cnidaria ... See more keywords
Post-transcriptional gene silencing triggers dispensable DNA methylation in gene body in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz636
Abstract: Abstract Spontaneous post-transcriptional silencing of sense transgenes (S-PTGS) is established in each generation and is accompanied by DNA methylation, but the pathway of PTGS-dependent DNA methylation is unknown and so is its role. Here we… read more here.
Keywords: methylation; gene body; ptgs; post transcriptional ... See more keywords
DNMT3B-Mediated Gene Body Methylation Suppresses Aberrant Transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-043
Abstract: DNMT3B methylates intragenic DNA to prevent spurious transcription from cryptic intragenic sites. read more here.
Keywords: transcription; dnmt3b; gene body; mediated gene ... See more keywords
Gene Body Methylation and Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-134964
Abstract: Introduction: Truncating mutations in Additional Sex Combs-Like 1 (ASXL1) are associated with a high-risk disease phenotype in myeloid malignancies. In chronic myelomonocytic leukemia (CMML), truncating ASXL1 mutations are known to increase transcriptional activity of leukemic… read more here.
Keywords: expression; gene; body methylation; gene body ... See more keywords
Proximal methylation features associated with nonrandom changes in gene body methylation
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1206-2
Abstract: BackgroundGene body methylation at CG dinucleotides is a widely conserved feature of methylated genomes but remains poorly understood. The Arabidopsis thaliana strain Cvi has depleted gene body methylation relative to the reference strain Col. Here,… read more here.
Keywords: methylation; gene body; body methylation; cgs ... See more keywords
Dnmt1a is essential for gene body methylation and the regulation of the zygotic genome in a wasp
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010181
Abstract: Gene body methylation (GBM) is an ancestral mode of DNA methylation whose role in development has been obscured by the more prominent roles of promoter and CpG island methylation. The wasp Nasonia vitripennis has little… read more here.
Keywords: methylation; gene body; wasp; gene ... See more keywords
Early Parity Epigenetic Footprint of FOXA1 Gene Body in Normal Breast Tissue of Iranian Women
Sign Up to like & getrecommendations! Published in 2019 at "Iranian biomedical journal"
DOI: 10.29252/ibj.23.2.99
Abstract: Background Young age at first full-term pregnancy (FFTP) is an important factor in breast cancer risk reduction. It is postulated that this protective effect is the result of stable molecular signatures imprinted by physiological process… read more here.
Keywords: normal breast; breast tissue; gene; gene body ... See more keywords