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   Articles with "gene cluster" as a keyword



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Double‐reporter‐guided targeted activation of the oxytetracycline silent gene cluster in Streptomyces rimosus M527

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recommendations! Published in 2023 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.28347

Abstract: In Streptomyces rimosus M527, the oxytetracycline (OTC) biosynthetic gene cluster is not expressed under laboratory conditions. In this study a reported‐guided mutant selection (RGMS) procedure was used to activate the cluster. The double‐reporter plasmid pAGT… read more here.

Keywords: pagt; cluster; rimosus m527; gene ... See more keywords
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Aromatic Polyketide GTRI‐02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2)

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700107

Abstract: The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC)… read more here.

Keywords: polyketide; act; gtri; gene cluster ... See more keywords
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Corrigendum: Biosynthetic Gene Cluster for Surugamide A Encompasses an Unrelated Decapeptide, Surugamide F

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700401

Abstract: The absolute configuration of the 3-amino-2-methyl propionic acid (AMPA) residue in surugamide F was assigned incorrectly, because the supplier erroneously provided the l-3-aminoisobutyric acid as d-3-aminoisobutyric acid and vice versa. Therefore, the absolute configuration of… read more here.

Keywords: surugamide; corrigendum biosynthetic; gene cluster; surugamide encompasses ... See more keywords
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Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation

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recommendations! Published in 2018 at "ChemBioChem"

DOI: 10.1002/cbic.201800266

Abstract: Silent biosynthetic gene clusters represent a potentially rich source of new bioactive compounds. We report the discovery, characterization, and biosynthesis of a novel doubly glycosylated 24‐membered polyene macrolactam from a silent biosynthetic gene cluster in… read more here.

Keywords: crispr cas9; gene cluster; streptomyces roseosporus; activation ... See more keywords
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Identifying the Biosynthetic Gene Cluster for Triacsins with an N‐Hydroxytriazene Moiety

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recommendations! Published in 2019 at "ChemBioChem"

DOI: 10.1002/cbic.201800762

Abstract: Triacsins are a family of natural products having in common an N‐hydroxytriazene moiety not found in any other known secondary metabolites. Though many studies have examined the biological activity of triacsins in lipid metabolism, their… read more here.

Keywords: biosynthetic gene; gene; hydroxytriazene moiety; gene cluster ... See more keywords
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Biosynthesis of the Isocoumarin Derivatives Fusamarins is Mediated by the PKS8 Gene Cluster in Fusarium

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200342

Abstract: Fusarium mangiferae causes the mango malformation disease (MMD) on young mango trees and seedlings resulting in economically significant crop losses. In addition, F. mangiferae produces a vast array of secondary metabolites (SMs), including mycotoxins that may… read more here.

Keywords: gene cluster; isocoumarin derivatives; biosynthesis isocoumarin; cluster ... See more keywords
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Polymorphisms in the IL‐1 gene cluster influence systemic inflammation in patients at risk for acute‐on‐chronic liver failure

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28896

Abstract: Acute‐on‐chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short‐term mortality. Recent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF… read more here.

Keywords: inflammation; gene cluster; aclf; failure ... See more keywords
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The miR‐15a/16 gene cluster in human cancer: A systematic review

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27342

Abstract: MicroRNAs (miRNAs) are an important class of endogenous small noncoding single‐stranded RNAs that suppress the expression of their target genes through messenger RNA (mRNA) degradation to inhibit transcription and translation. MiRNAs play a crucial regulatory… read more here.

Keywords: 15a gene; cluster human; mir 15a; gene cluster ... See more keywords
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Estimating the age of Hb G‐Coushatta [β22(B4)Glu→Ala] mutation by haplotypes of β‐globin gene cluster in Denizli, Turkey

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recommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.404

Abstract: Hb G‐Coushatta variant was reported from various populations’ parts of the world such as Thai, Korea, Algeria, Thailand, China, Japan and Turkey. In our study, we aimed to discuss the possible historical relationships of the… read more here.

Keywords: globin gene; coushatta; denizli turkey; gene cluster ... See more keywords
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Association of C1q gene cluster variants with rheumatoid arthritis: a pilot study

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recommendations! Published in 2022 at "Rheumatology International"

DOI: 10.1007/s00296-022-05089-1

Abstract: Single-nucleotide polymorphisms (SNPs) in C1q gene cluster were previously linked to autoimmunity and SLE, but data are scarce for their association with RA. In the present study, we evaluated associations of five SNPs (rs665691, rs682658,… read more here.

Keywords: study; c1q; gene cluster; association ... See more keywords
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Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragments

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recommendations! Published in 2017 at "Science China Life Sciences"

DOI: 10.1007/s11427-017-9119-1

Abstract: Genetic modification of large DNA fragments (gene clusters) is of great importance in synthetic biology and combinatorial biosynthesis as it facilitates rational design and modification of natural products to increase their value and productivity. In… read more here.

Keywords: modification large; gene cluster; biology; gene ... See more keywords