Identification of Oral Bacterial Biosynthetic Gene Clusters Associated with Caries.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1518-8_10
Abstract: Small molecules are a primary communication media of the microbial world, and play crucial, yet largely unidentified, roles in microbial ecology and disease pathogenesis. Many small molecules are produced by biosynthetic gene clusters, which can… read more here.
Keywords: identification oral; oral bacterial; biosynthetic gene; gene clusters ... See more keywords
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09708-z
Abstract: Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional interest owing to their unique biomedical ramifications. The traditional discovery of new natural products that was mainly driven by bioactivity screening has… read more here.
Keywords: detecting prioritizing; prioritizing biosynthetic; biosynthetic gene; gene clusters ... See more keywords
Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11192-3
Abstract: Fungal terpenoids catalyzed by bifunctional terpene synthases (BFTSs) possess interesting bioactive and chemical properties. In this study, an integrated approach of genome mining, heterologous expression, and in vitro enzymatic activity assay was used, and these… read more here.
Keywords: phytopathogenic fungi; trans fused; genome; gene clusters ... See more keywords
Expansion of gene clusters, circular orders, and the shortest Hamiltonian path problem
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-017-1197-3
Abstract: Clusters of paralogous genes such as the famous HOX cluster of developmental transcription factors tend to evolve by stepwise duplication of its members, often involving unequal crossing over. Gene conversion and possibly other mechanisms of… read more here.
Keywords: expansion gene; unequal crossing; shortest hamiltonian; gene clusters ... See more keywords
A chromatogram-simplified Streptomyces albus host for heterologous production of natural products
Sign Up to like & getrecommendations! Published in 2019 at "Antonie Van Leeuwenhoek"
DOI: 10.1007/s10482-019-01360-x
Abstract: Cloning natural product biosynthetic gene clusters from cultured or uncultured sources and their subsequent expression by genetically tractable heterologous hosts is an essential strategy for the elucidation and characterisation of novel microbial natural products. The… read more here.
Keywords: streptomyces albus; natural products; chromatogram simplified; simplified streptomyces ... See more keywords
Draft genome and secondary metabolite biosynthetic gene clusters of Streptomyces sp. strain 196.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05731-w
Abstract: Emergence of MDR 'superbugs' inflamed a severe sense of urgency amongst scientists aiming at the discovery of novel potential drug molecules. Bacteria of the genus Streptomyces are really worth investigating for their immense potential to… read more here.
Keywords: secondary metabolite; streptomyces strain; strain 196; gene clusters ... See more keywords
Current strategies to induce secondary metabolites from microbial biosynthetic cryptic gene clusters
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Microbiology"
DOI: 10.1007/s13213-018-1351-1
Abstract: The genome of actinomycetes and several other microorganisms are endowed with many cryptic gene clusters that can code for previously undetected, a plethora of complex secondary metabolites. Under standard laboratory controlled conditions, the genes regulating… read more here.
Keywords: strategies induce; current strategies; cryptic gene; gene clusters ... See more keywords
Epigenetic modulations of mycoendophytes for novel bioactive molecules
Sign Up to like & getrecommendations! Published in 2018 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2018.09.025
Abstract: Abstract The need for new analogues with higher efficacy to combat the multidrug-resistant microbes as well as other health implications is the need of the hour. Medicinal chemistry has been focused highly in this regard… read more here.
Keywords: mycoendophytes novel; modulations mycoendophytes; novel bioactive; biosynthetic gene ... See more keywords
Characterization of the secondary metabolite biosynthetic gene clusters in archaea
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.11.019
Abstract: Secondary metabolites are a range of bioactive compounds yielded by bacteria, fungi and plants, etc. The published archaea genomic data provide the opportunity for efficient identification of secondary metabolite biosynthetic gene clusters (BGCs) by genome… read more here.
Keywords: biosynthetic gene; gene clusters; secondary metabolite; metabolite biosynthetic ... See more keywords
Challenges of functional expression of complex polyketide biosynthetic gene clusters.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.12.007
Abstract: Polyketide natural products are valuable sources of bioactive molecules such as nutraceuticals and pharmaceuticals. The tremendous development of the genome sequence database revealed that the majority of the biosynthetic gene clusters (BGCs) are cryptic. Activation… read more here.
Keywords: biosynthetic gene; gene clusters; challenges functional; functional expression ... See more keywords
Diversity and evolution of polyketide biosynthesis gene clusters in the Ceratocystidaceae.
Sign Up to like & getrecommendations! Published in 2018 at "Fungal biology"
DOI: 10.1016/j.funbio.2018.04.011
Abstract: Polyketides are secondary metabolites with diverse biological activities. Polyketide synthases (PKS) are often encoded from genes clustered in the same genomic region. Functional analyses and genomic studies show that most fungi are capable of producing… read more here.
Keywords: gene clusters; biology; polyketide biosynthesis; biosynthesis gene ... See more keywords