Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23508-x
Abstract: Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved… read more here.
Keywords: gene; stress; gene conversion; purifying selection ... See more keywords
Monoclonal antibody generation by controlled immunoglobulin gene rearrangements
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07690-z
Abstract: Monoclonal antibodies (mAbs) are essential for various applications including experimental reagents, diagnostics, and therapeutics. Thus, the platform technologies that stably generate antigen-specific mAbs are increasingly crucial. We previously developed a method to generate mAbs, termed… read more here.
Keywords: gene; adlib system; gene conversion; antigen specific ... See more keywords
Disclosing complex mutational dynamics at a Y chromosome palindrome evolving through intra- and inter-chromosomal gene conversion.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac144
Abstract: The human MSY ampliconic region is mainly composed of large duplicated sequences that are organized in eight palindromes (termed P1-P8), and may undergo arm-to-arm gene conversion. Although the importance of these elements is widely recognised,… read more here.
Keywords: chromosomal gene; gene conversion; intra inter; gene ... See more keywords
Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaf168
Abstract: GC-biased gene conversion (gBGC) is a widespread evolutionary force associated with meiotic recombination that favours the accumulation of deleterious AT to GC substitutions in proteins, moving them away from their fitness optimum. In many mammals… read more here.
Keywords: biased gene; evolution; gene conversion; compensatory evolution ... See more keywords
Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1167
Abstract: Abstract In vertebrates, genomic DNA double-strand breaks (DSBs) are removed by non-homologous end-joining processes: classical non-homologous end-joining (c-NHEJ) and alternative end-joining (alt-EJ); or by homology-dependent processes: gene-conversion (GC) and single-strand annealing (SSA). Surprisingly, these repair… read more here.
Keywords: suppression; gene conversion; dna double; strand ... See more keywords
Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence data
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1101/2024.12.30.630818
Abstract: Non-crossover gene conversion is a type of meiotic recombination characterized by the non-reciprocal transfer of genetic material between homologous chromosomes. Gene conversions are thought to occur within relatively short tracts of DNA. However, the number… read more here.
Keywords: length; distribution; conversion tracts; gene conversion ... See more keywords
Evidence for a gene conversion in a Hb Arya Carrier [α codon 47 Asp>Asn, Hb A1(or Hb A2):c.142 G>A]
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.12609
Abstract: Adult hemoglobin (HbA) is a tetramer formed by the association of a and b chains (a2b2) which are encoded onto different loci. The two a adult genes, HBA1 and HBA2, are located on chromosome 16… read more here.
Keywords: amino acid; gene conversion; carrier; gene ... See more keywords
Pervasive gene conversion in chromosomal inversion heterozygotes
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Ecology"
DOI: 10.1111/mec.14921
Abstract: Chromosomal inversions shape recombination landscapes, and species differing by inversions may exhibit reduced gene flow in these regions of the genome. Though single crossovers within inversions are not usually recovered from inversion heterozygotes, the recombination… read more here.
Keywords: conversion rates; gene; inversion heterozygotes; gene conversion ... See more keywords
Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-07776-y
Abstract: Background Duplicated gene pairs produced by ancient polyploidy maintain high sequence similarity over a long period of time and may result from illegitimate recombination between homeologous chromosomes. The genomes of Asian cultivated rice Oryza sativa… read more here.
Keywords: gene conversion; rice subspecies; conversion; duplicated genes ... See more keywords
Role for gene conversion in the evolution of cell-surface antigens of the malaria parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002507
Abstract: While the malaria parasite Plasmodium falciparum has low average genome-wide diversity levels, likely due to its recent introduction from a gorilla-infecting ancestor (approximately 10,000 to 50,000 years ago), some genes display extremely high diversity levels.… read more here.
Keywords: diversity; surface; gene conversion; falciparum ... See more keywords
Biased Gene Conversion Constrains Adaptation in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303335
Abstract: Reduction of fitness due to deleterious mutations imposes a limit to adaptive evolution. By characterizing features that influence this genetic load we may better understand constraints on responses to both natural and human-mediated selection. Here,… read more here.
Keywords: gene; biased gene; arabidopsis thaliana; gene conversion ... See more keywords