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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23508-x
Abstract: Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved…
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Keywords:
gene;
stress;
gene conversion;
purifying selection ... See more keywords
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Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac144
Abstract: The human MSY ampliconic region is mainly composed of large duplicated sequences that are organized in eight palindromes (termed P1-P8), and may undergo arm-to-arm gene conversion. Although the importance of these elements is widely recognised,…
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Keywords:
chromosomal gene;
gene conversion;
intra inter;
gene ... See more keywords
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Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1167
Abstract: Abstract In vertebrates, genomic DNA double-strand breaks (DSBs) are removed by non-homologous end-joining processes: classical non-homologous end-joining (c-NHEJ) and alternative end-joining (alt-EJ); or by homology-dependent processes: gene-conversion (GC) and single-strand annealing (SSA). Surprisingly, these repair…
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Keywords:
suppression;
gene conversion;
dna double;
strand ... See more keywords
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Published in 2017 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.12609
Abstract: Adult hemoglobin (HbA) is a tetramer formed by the association of a and b chains (a2b2) which are encoded onto different loci. The two a adult genes, HBA1 and HBA2, are located on chromosome 16…
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Keywords:
amino acid;
gene conversion;
carrier;
gene ... See more keywords
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Published in 2019 at "Molecular Ecology"
DOI: 10.1111/mec.14921
Abstract: Chromosomal inversions shape recombination landscapes, and species differing by inversions may exhibit reduced gene flow in these regions of the genome. Though single crossovers within inversions are not usually recovered from inversion heterozygotes, the recombination…
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Keywords:
conversion rates;
gene;
inversion heterozygotes;
gene conversion ... See more keywords
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Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-07776-y
Abstract: Background Duplicated gene pairs produced by ancient polyploidy maintain high sequence similarity over a long period of time and may result from illegitimate recombination between homeologous chromosomes. The genomes of Asian cultivated rice Oryza sativa…
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Keywords:
gene conversion;
rice subspecies;
conversion;
duplicated genes ... See more keywords
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Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303335
Abstract: Reduction of fitness due to deleterious mutations imposes a limit to adaptive evolution. By characterizing features that influence this genetic load we may better understand constraints on responses to both natural and human-mediated selection. Here,…
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Keywords:
gene;
biased gene;
arabidopsis thaliana;
gene conversion ... See more keywords
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Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017050518
Abstract: Atypical hemolytic uremic syndrome (aHUS), a rare form of thrombotic microangiopathy caused by complement pathogenic variants, mainly affects the kidney microvasculature. A retrospective genetic analysis in our aHUS cohort (n=513) using multiple ligation probe amplification…
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Keywords:
atypical hemolytic;
uremic syndrome;
gene conversion;
hemolytic uremic ... See more keywords
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Published in 2018 at "Frontiers in Ecology and Evolution"
DOI: 10.3389/fevo.2018.00203
Abstract: It is well established that GC content varies across the genome in many species and that GC biased gene conversion, one form of meiotic recombination, is likely to contribute to this heterogeneity. Bird genomes provide…
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Keywords:
gene conversion;
fixation bias;
genome;
biased gene ... See more keywords
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Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00054
Abstract: The male-specific region of the human Y chromosome (MSY) is characterized by the lack of meiotic recombination and it has long been considered an evolutionary independent region of the human genome. In recent years, however,…
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Keywords:
region human;
gene conversion;
chromosomal gene;
inter chromosomal ... See more keywords
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Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.01076
Abstract: Polyploidies produce a large number of duplicated regions and genes in genomes, which have a long-term impact and stimulate genetic innovation. The high similarity between homeologous chromosomes, forming different subgenomes, or homologous regions after genome…
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Keywords:
wheat genome;
recombination homeologous;
gene conversion;
illegitimate recombination ... See more keywords