Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β‐catenin‐EGFR‐PI3K‐Akt‐mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22747
Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and represents a highly malignant tumor with a poor prognosis. Therapeutic modalities for HCC are limited and generally ineffective. UBE2Q1 is a putative E2… read more here.
Keywords: hepatocellular carcinoma; egfr pi3k; hcc; pi3k akt ... See more keywords
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.07.006
Abstract: Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer… read more here.
Keywords: number changes; copy number; gene copy; number ... See more keywords
A model for the impact of FFPE section thickness on gene copy number measurement by FISH
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44015-7
Abstract: Fluorescent in situ hybridization (FISH) assays to detect gene amplification such as HER2 or MET in tumors are used for prognosis evaluation and selection of targeted therapies. Although FISH guidelines recommended 4~6 μm FFPE sections,… read more here.
Keywords: copy number; section thickness; gene copy; model ... See more keywords
Gene copy number is associated with phytochemistry in Cannabis sativa
Sign Up to like & getrecommendations! Published in 2019 at "AoB Plants"
DOI: 10.1093/aobpla/plz074
Abstract: Abstract Gene copy number (CN) variation is known to be important in nearly every species where it has been examined. Alterations in gene CN may provide a fast way of acquiring diversity, allowing rapid adaptation… read more here.
Keywords: copy number; variation; gene copy; cannabis sativa ... See more keywords
Gene copy number variation and pediatric mental health/neurodevelopment in a general population.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad074
Abstract: We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognition in a community sample of 7100 unrelated children and youth of European or East Asian… read more here.
Keywords: gene copy; health; copy number; mental health ... See more keywords
Combined epigenetic signature and gene copy number variations in IDH-mutant glioblastomas showed varied risk stratification
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz167.006
Abstract: The number of IDH-mutant glioblastoma examined in the literature and TCGA is few. We used Infinium MethylationEPIC BeadChip array to classify 64 IDH-mutant-GBM into methylation groups. Gene copy number variations were determined from methylation. 53.1%,… read more here.
Keywords: gene copy; group; copy number; idh mutant ... See more keywords
Gene copy number variations in adaptive evolution: The genomic distribution of gene copy number variations revealed by genetic mapping and their adaptive role in an undomesticated species, white spruce (Picea glauca)
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Ecology"
DOI: 10.1111/mec.14337
Abstract: Gene copy number variation (CNV) has been associated with phenotypic variability in animals and plants, but a genomewide understanding of their impacts on phenotypes is largely restricted to human and agricultural systems. As such, CNVs… read more here.
Keywords: copy number; number variations; gene copy; cnvs ... See more keywords
Carbapenemase-Encoding Gene Copy Number Estimator (CCNE): a Tool for Carbapenemase Gene Copy Number Estimation
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01000-22
Abstract: Globally disseminated carbapenem-resistant Enterobacterales is an urgent threat to public health. The most common carbapenem resistance mechanism is the production of carbapenemases. ABSTRACT Carbapenemase production is one of the leading mechanisms of carbapenem resistance in… read more here.
Keywords: gene copy; carbapenemase; copy number; copy ... See more keywords
SAT0424 Complement c4 gene copy number variations bestow large ranges of serum c4 protein levels in chinese patients with systemic lupus erythematosus (SLE) and contribute to organ and cardiovascular damages over time
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4974
Abstract: Background Human SLE is characterised by fluctuating serum levels of complement proteins. There are frequent copy number variations (CNVs) of complement C4A and C4B genes among different individuals. Previously, we demonstrated that C4A deficiency is… read more here.
Keywords: sle; serum; gene copy; serum levels ... See more keywords
Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5450-6
Abstract: BackgroundsSince Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal… read more here.
Keywords: copy number; met gene; gene copy; met fish ... See more keywords
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer
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DOI: 10.1371/journal.pone.0181527
Abstract: Introduction To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression,… read more here.
Keywords: negative prognostic; met igf; gene copy; expression ... See more keywords