Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700478
Abstract: Introducing novel shapes to particulate carrier systems adds unique features to modern drug and gene delivery. Depending on the route of administration, particle geometry can influence deposition and fate within biological environments. In this work,… read more here.
Keywords: alveolar macrophages; aspherical nanostructured; delivery; nanostructured microparticles ... See more keywords
Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104979
Abstract: Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte-centered diseases requires efficient and well-characterized gene transfer vectors. Vectors derived from the Adeno-associated virus… read more here.
Keywords: adeno associated; raav9p1; gene; human astrocytes ... See more keywords
Chemically Tuned Intracellular Gene Delivery by Core-Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100718
Abstract: Nanoparticles consisting of a condensed nucleic acid core surrounded by protective layers which aid to overcome extracellular and intracellular hurdles to gene delivery (i. e., core‐shell nanoparticles, CSNPs) synthetically mimic viruses. The outer shells shield the… read more here.
Keywords: core; intracellular gene; gene delivery; gene ... See more keywords
Conjugated Polymers for Gene Delivery and Photothermal Gene Expression.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202200073
Abstract: Gene therapy has attracted great attention due to its applications in disease treatment. The key point for gene therapy is how to improve the efficiency of gene delivery and precisely control gene expression. Conjugated polymers… read more here.
Keywords: gene expression; conjugated polymers; gene delivery; gene ... See more keywords
The Role of Formamidine Groups in Dextran Based Nonviral Vectors for Gene Delivery on Their Physicochemical and Biological Characteristics.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000220
Abstract: Dextran-formamidine esters (dextran-N-[(dimethylamino)methylene]-β-alanine ester) with different degrees of substitution (0.45-0.92) are synthesized in an one-pot reaction. Dextran (Mw 60 000 g mol-1 ) is allowed to react with unprotected beta-alanine and iminium chloride and investigated regarding… read more here.
Keywords: gene delivery; role; formamidine groups; gene ... See more keywords
Intraputaminal Gene Delivery in Two Patients with Aromatic L‐Amino Acid Decarboxylase Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13685
Abstract: Aromatic l‐amino acid decarboxylase deficiency (AADCD) is a rare, early‐onset, dyskinetic encephalopathy mostly reflecting a defective synthesis of brain dopamine and serotonin. Intracerebral gene delivery (GD) provided a significant improvement among AADCD patients (mean age,… read more here.
Keywords: acid decarboxylase; decarboxylase deficiency; amino acid; aromatic amino ... See more keywords
Extracellular Vesicles: A Prevalent Tool for Microbial Gene Delivery?
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201800170
Abstract: Genetic plasticity of prokaryotic microbial communities is largely dependent on the ongoing exchange of genetic determinants by Horizontal Gene Transfer (HGT). HGT events allow beneficial genetic transitions to occur throughout microbial life, thus promoting adaptation… read more here.
Keywords: extracellular vesicles; prevalent tool; vesicles prevalent; gene delivery ... See more keywords
Novel Nanoencapsulation Technology and its Potential Role in Bile Acid-Based Targeted Gene Delivery to the Inner Ear.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204986
Abstract: Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in particular the sensitive hair cells, can impact individuals for the rest of their lives. There are very limited options… read more here.
Keywords: inner ear; nanoencapsulation; targeted gene; gene delivery ... See more keywords
Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1853
Abstract: Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene therapy applications, utilizing a range of lipid-based, polymeric, and inorganic materials. These materials can either encapsulate or be functionalized to bind nucleic… read more here.
Keywords: brain; cns neurological; gene delivery; gene ... See more keywords
Cardiac Gene Delivery Using Recirculating Devices.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6588-5_19
Abstract: Cardiac gene delivery has become an important issue following the emergence of gene therapy for the possible treatment of heart failure. Despite many advances in the management of heart failure (HF), treatment options for many… read more here.
Keywords: heart; delivery; gene delivery; cardiac gene ... See more keywords
A Novel Gene Delivery Approach Using Metal Organic Frameworks in Human Islet-Derived Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9631-5_7
Abstract: The ability to regenerate insulin-producing β cells is the ultimate goal for treatment of type 1 diabetes. Several sources of stem cells have been investigated by studying their differential potential to form insulin-producing β cells… read more here.
Keywords: progenitor cells; delivery; metal organic; gene delivery ... See more keywords