Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12489
Abstract: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for aromatic L-amino acid hydroxylases, including tyrosine hydroxylase (TH), alkylglycerol monooxygenase and three types of nitric oxide synthases (NOS). Sepiapterin reductase (SPR) catalyzes the third step of BH4 biosynthesis.… read more here.
Keywords: hypofunction sympathetic; gene disrupted; mice; priapism ... See more keywords
Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK
Sign Up to like & getrecommendations! Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4818-7
Abstract: ObjectiveNRK is a unique X chromosome-linked protein kinase expressed predominantly in placenta. The gene knockout causes placental overgrowth and delayed labor of Nrk-null fetuses from dams in mouse. To clarify unknown mechanisms behind the Nrk-null… read more here.
Keywords: nrk gene; nrk null; proteomic analysis; analysis nrk ... See more keywords