Loop-mediated isothermal amplification (LAMP) as an alternative to PCR: A rapid on-site detection of gene doping.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2324
Abstract: Innovation in medical research has been diverted at multiple occasions to enhance human performance. The predicted great progress in gene therapy has raised some concerns regarding its misuse in the world of sports (gene doping)… read more here.
Keywords: loop mediated; mediated isothermal; detection; isothermal amplification ... See more keywords
A Quantitative PCR Screening Method for Adeno-Associated Viral Vector 2-mediated Gene Doping.
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DOI: 10.1002/dta.3152
Abstract: Gene therapy is currently prohibited in human and equine athletes and novel analytical methods are needed for its detection. Most in vivo products use non-integrating, recombinant viral vectors derived from adeno-associated virus (AAV) to deliver… read more here.
Keywords: quantitative pcr; gene doping; raav; adeno associated ... See more keywords
Low-copy transgene detection using nested digital PCR for gene doping control.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3173
Abstract: Gene doping is prohibited for fair competition in human and horse sports. One style of gene doping is the administration of an exogeneous gene, called a transgene, to postnatal humans and horses. Although many transgene… read more here.
Keywords: detection; pcr; gene doping; digital pcr ... See more keywords
Direct sequence confirmation of qPCR products for gene doping assay validation in horses.
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DOI: 10.1002/dta.3219
Abstract: The misuse of gene therapy by the introduction of transgenes via plasmid or viral vectors as a doping agent is an increasing concern in human and animal sports, not only in consideration to fair competition… read more here.
Keywords: qpcr products; gene doping; sequence; confirmation ... See more keywords
Optimization and implementation of four duplex qPCR assays for gene doping control in horseracing.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3328
Abstract: The concern about gene doping has remained high in horseracing and other equestrian competitions. Our laboratory has previously developed a duplex quantitative polymerase chain reaction (qPCR) assay capable of detecting in equine blood the human… read more here.
Keywords: four duplex; gene; control; duplex qpcr ... See more keywords
Towards a robust test to detect gene doping for anabolic enhancement in human athletes.
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DOI: 10.1002/dta.3411
Abstract: Success in gene therapy in treating human disease makes this technology attractive to enhance athletic performance, creating the need for gene doping detection. In 2021, WADA approved the first gene doping test. Here we describe… read more here.
Keywords: gene; test; method; blood ... See more keywords
Gene doping detection in the era of genomics.
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DOI: 10.1002/dta.3664
Abstract: Recent progress in gene editing has enabled development of gene therapies for many genetic diseases, but also made gene doping an emerging risk in sports and competitions. By delivery of exogenous transgenes into human body,… read more here.
Keywords: era genomics; gene; gene doping; doping detection ... See more keywords
Microfluidic Quantitative PCR Detection of 12 Transgenes from Horse Plasma for Gene Doping Control
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11040457
Abstract: Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods… read more here.
Keywords: detection; doping control; microfluidic quantitative; gene doping ... See more keywords
Detection Method for Gene Doping in a Mouse Model Expressing Human Erythropoietin from Adeno-Associated Virus Vector-9
Sign Up to like & getrecommendations! Published in 2024 at "Genes"
DOI: 10.3390/genes15060709
Abstract: With the rapid development of gene therapy technology in recent years, its abuse as a method of sports doping in athletics has become a concern. However, there is still room for improvement in gene-doping testing… read more here.
Keywords: adeno associated; virus vector; gene doping; model ... See more keywords