Abstract 2461: The cell migration inhibitor dihydromotuporamine C regulates actin-myosin contractility and actin polymerization
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2461
Abstract: The motuporamines are a promising class of anti-metastatic compounds. Dihydromotuporamine C (Motu33) has been shown to activate the small GTPase RhoA, however, little is known about subsequent downstream events leading to cell migration inhibition. In… read more here.
Keywords: actin myosin; actin polymerization; activity; myosin ... See more keywords
Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.756262
Abstract: A male sex bias has emerged in the COVID-19 pandemic, fitting to the sex-biased pattern in other viral infections. Males are 2.84 times more often admitted to the ICU and mortality is 1.39 times higher… read more here.
Keywords: covid; gene; sex; dose effect ... See more keywords
Increased TPSAB1 Copy Number in a Family With Elevated Basal Serum Levels of Tryptase
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DOI: 10.3389/fmed.2021.577081
Abstract: Background: Some recent familial studies have described a pattern of autosomal dominant inheritance for increased basal serum tryptase (BST), but no correlation with mRNA expression and gene dose have been reported. Objective: We analyzed TPSAB1… read more here.
Keywords: basal serum; copy number; gene dose; family ... See more keywords
From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19
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DOI: 10.3389/fphar.2023.1076574
Abstract: Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide… read more here.
Keywords: allele tools; cyp2c19 gene; gene dose; read sequencing ... See more keywords
Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose
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DOI: 10.7554/elife.61172
Abstract: Aneuploidy causes birth defects and miscarriages, occurs in nearly all cancers and is a hallmark of aging. Individual aneuploid cells can be eliminated from developing tissues by unknown mechanisms. Cells with ribosomal protein (Rp) gene… read more here.
Keywords: gene dose; competition; aneuploid cells; cell competition ... See more keywords