Stakeholder engagement to inform the risk assessment and governance of gene drive technology to manage spotted-wing drosophila.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2022.114480
Abstract: Emerging biotechnologies, such as gene drive technology, are increasingly being proposed to manage a variety of pests and invasive species. As one method of genetic biocontrol, gene drive technology is currently being developed to manage… read more here.
Keywords: swd gene; gene drive; drive technology; technology ... See more keywords
Conditions for success of engineered underdominance gene drive systems
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2017.07.014
Abstract: Highlights • A model of engineered underdominance (UD) gene drive is proposed.• Numerical results suggest that UD could be an effective tool for disease control.• Success/failure of UD is affected by release strategy and fitness… read more here.
Keywords: underdominance gene; conditions success; engineered underdominance; gene drive ... See more keywords
Applications of gene drive systems for population suppression of insect pests
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of Entomological Research"
DOI: 10.1017/s0007485322000268
Abstract: Abstract Population suppression is an effective way for controlling insect pests and disease vectors, which cause significant damage to crop and spread contagious diseases to plants, animals and humans. Gene drive systems provide innovative opportunities… read more here.
Keywords: drive systems; gene; population suppression; gene drive ... See more keywords
Can CRISPR-Based Gene Drive Be Confined in the Wild? A Question for Molecular and Population Biology.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00923
Abstract: The recent discovery of CRISPR and its application as a gene editing tool has enabled a range of gene drive systems to be engineered with greater ease. In order for the benefits of this technology… read more here.
Keywords: gene drive; drive systems; biology crispr; biology ... See more keywords
Gene drives thwarted by emergence of resistant organisms
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/542015a
Abstract: I n the small city of Terni in central Italy, researchers are putting the final touches on what could be the world's most sophisticated mosquito cages. The enclosures, each occupying 150 cubic metres, simulate the… read more here.
Keywords: gene drive; thwarted emergence; drives thwarted; gene ... See more keywords
Rules of the road for insect gene drive research and testing
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3926
Abstract: Approximately two years ago, two of us (E.B. and V.G.) demonstrated the first experimental application of CRISPR–Cas9 to 'drive' a desired trait throughout a population of fruit flies. In November 2015, this same team at… read more here.
Keywords: gene drive; rules road; road insect; drive ... See more keywords
A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13649-6
Abstract: Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage. In the presence… read more here.
Keywords: antibiotic resistance; gene; drive system; gene drive ... See more keywords
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19426-0
Abstract: Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification… read more here.
Keywords: population modification; gene; drive; gene drive ... See more keywords
Optimized CRISPR tools and site-directed transgenesis towards gene drive development in Culex quinquefasciatus mosquitoes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23239-0
Abstract: Culex mosquitoes are a global vector for multiple human and animal diseases, including West Nile virus, lymphatic filariasis, and avian malaria, posing a constant threat to public health, livestock, companion animals, and endangered birds. While… read more here.
Keywords: gene drive; culex quinquefasciatus; culex; transgenesis ... See more keywords
Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24790-6
Abstract: CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this… read more here.
Keywords: mosquito populations; gene drive; field; cages bridge ... See more keywords
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-0508-1
Abstract: Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex… read more here.
Keywords: distorter gene; gene drive; malaria vector; sex ... See more keywords