Nuclease-based gene drives, an innovative tool for insect vector control: advantages and challenges of the technology.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2020.03.007
Abstract: Genetic control of insects involves the release of modified insects that contain altered genetic traits and are competent to mate with target populations to introduce the traits therein. Since it relies on mating, this type… read more here.
Keywords: insects; control; advantages challenges; technology ... See more keywords
Gene drives thwarted by emergence of resistant organisms
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/542015a
Abstract: I n the small city of Terni in central Italy, researchers are putting the final touches on what could be the world's most sophisticated mosquito cages. The enclosures, each occupying 150 cubic metres, simulate the… read more here.
Keywords: gene drive; thwarted emergence; drives thwarted; gene ... See more keywords
Ban on ‘gene drives’ is back on the UN’s agenda — worrying scientists
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-07436-4
Abstract: Research is moving fast on the divisive genetic technology, which could help to eradicate diseases but also risks altering ecosystems in unpredictable ways.The divisive genetic technology could help to eradicate diseases but also risks altering… read more here.
Keywords: drives back; ban gene; agenda worrying; worrying scientists ... See more keywords
UN treaty agrees to limit gene drives but rejects a moratorium
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-07600-w
Abstract: Treaty’s vague language on how researchers can release engineered organisms has both opponents and supporters of the technology claiming victory. Treaty's vague language on how researchers can release engineered organisms has both opponents and supporters… read more here.
Keywords: drives rejects; limit gene; agrees limit; treaty ... See more keywords
Propagation of seminal toxins through binary expression gene drives could suppress populations
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10327-4
Abstract: Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to… read more here.
Keywords: gene drives; binary expression; gene; spread ... See more keywords
Gene drives may be the next step towards sustainable control of malaria
Sign Up to like & getrecommendations! Published in 2017 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2017.1453587
Abstract: Invited commentary on ‘Gene drives to fight malaria: current state and future directions.’ A recent review by Hammond and Galizi [1] discusses the technical progress and challenges of using gene drive based technologies for malaria… read more here.
Keywords: gene drive; control; drive; resistance ... See more keywords
Gene drives to fight malaria: current state and future directions
Sign Up to like & getrecommendations! Published in 2017 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2018.1438880
Abstract: Abstract Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining,… read more here.
Keywords: fight malaria; malaria current; drives fight; current state ... See more keywords
Genes drive organisms and slippery slopes.
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens and global health"
DOI: 10.1080/20477724.2022.2160895
Abstract: The bioethical debate about using gene drives to alter or eradicate wild populations has focused mostly on issues concerning short-term risk assessment and management, governance and oversight, and public and community engagement, but has not… read more here.
Keywords: slippery; slippery slope; gene; drive organisms ... See more keywords
Facilitating the Conversation: Gene Drive Classification.
Sign Up to like & getrecommendations! Published in 2021 at "Health security"
DOI: 10.1089/hs.2021.0109
Abstract: Gene drives are an emerging technology with tremendous potential to impact public health, agriculture, and conservation. While gene drives can be described simply as selfish genetic elements (natural or engineered) that are inherited at non-Mendelian… read more here.
Keywords: gene drive; drive classification; gene; gene drives ... See more keywords
iGEM and Gene Drives: A Case Study for Governance
Sign Up to like & getrecommendations! Published in 2022 at "Health Security"
DOI: 10.1089/hs.2021.0157
Abstract: Gene drives have already challenged governance systems. In this case study, we explore the International Genetically Engineered Machine (iGEM) competition's experiences in gene drive-related research and lessons in developing, revising, and implementing a governance system.… read more here.
Keywords: governance; case study; gene; gene drives ... See more keywords
Evolutionary dynamics of CRISPR gene drives
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1601964
Abstract: Previous CRISPR gene drives should undergo limited spread due to resistance, and a potential solution is presented. The alteration of wild populations has been discussed as a solution to a number of humanity’s most pressing… read more here.
Keywords: crispr gene; dynamics crispr; gene; evolutionary dynamics ... See more keywords