Redox-Responsive and Drug-Embedded Silica Nanoparticles with Unique Self-Destruction Features for Efficient Gene/Drug Codelivery
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201606229
Abstract: The development of advanced gene/drug codelivery carriers with stimuli-responsive release manner for complementary cancer therapy is desirable. In this study, novel disulfide-bridged and doxorubicin (DOX)-embedded degradable silica nanoparticles (DS-DOX) with unique self-destruction features are synthesized… read more here.
Keywords: destruction; gene drug; drug; codelivery ... See more keywords
Challenges and lessons learned from clinical pharmacogenetic implementation of multiple gene–drug pairs across ambulatory care settings
Sign Up to like & getrecommendations! Published in 2019 at "Genetics in Medicine"
DOI: 10.1038/s41436-019-0500-7
Abstract: PurposeIncorporating a patient’s genotype into the clinical decision-making process is one approach to precision medicine. The University of Florida (UF) Health Precision Medicine Program is a pharmacist-led multidisciplinary effort that has led the clinical implementation… read more here.
Keywords: medicine; implementation; drug pairs; gene drug ... See more keywords
Revealing protein networks and gene-drug connectivity in cancer from direct information
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04001-3
Abstract: The connection between genetic variation and drug response has long been explored to facilitate the optimization and personalization of cancer therapy. Crucial to the identification of drug response related genetic features is the ability to… read more here.
Keywords: protein; direct information; gene drug; drug ... See more keywords
GDISC: a web portal for integrative analysis of gene-drug interaction for survival in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw830
Abstract: Survival analysis has been applied to The Cancer Genome Atlas (TCGA) data. Although drug exposure records are available in TCGA, existing survival analyses typically did not consider drug exposure, partly due to naming inconsistencies in… read more here.
Keywords: gene drug; gdisc; drug; cancer ... See more keywords
HOGMMNC: a higher order graph matching with multiple network constraints model for gene‐drug regulatory modules identification
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty662
Abstract: Motivation: The emergence of large amounts of genomic, chemical, and pharmacological data provides new opportunities and challenges. Identifying gene‐drug associations is not only crucial in providing a comprehensive understanding of the molecular mechanisms of drug… read more here.
Keywords: higher order; gene drug; drug; order graph ... See more keywords
Identify Multiple Gene-Drug Common Modules via Constrained Graph Matching
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2022.3188503
Abstract: Identifying gene-drug interactions is vital to understanding biological mechanisms and achieving precise drug repurposing. High-throughput technologies produce a large amount of pharmacological and genomic data, providing an opportunity to explore the associations between oncogenic genes… read more here.
Keywords: drug common; common modules; gene drug; graph matching ... See more keywords
Retrospective Review of Pharmacogenetic Testing at an Academic Children’s Hospital
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12895
Abstract: There is limited evidence to support pharmacogenetic (PGx) testing in children. We conducted a retrospective review of PGx testing among 452 patients at an academic children’s hospital to determine the potential utility of PGx in… read more here.
Keywords: pgx; gene drug; drug; retrospective review ... See more keywords
The Importance of Gene-Drug-Drug-Interactions in Pharmacogenomics Decision Support: An Analysis Based on Austrian Claims Data
Sign Up to like & getrecommendations! Published in 2017 at "Studies in health technology and informatics"
DOI: 10.3233/978-1-61499-759-7-121
Abstract: While pharmacogenomic testing combined with clinical decision support has the potential to increase the safety and efficacy of medical treatments, the intake of multiple prescription drugs can - if not sufficiently addressed by decision support… read more here.
Keywords: drug; claims data; gene drug; decision support ... See more keywords
A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00183
Abstract: Usher syndrome is a genetic disorder causing neurosensory hearing loss and blindness from retinitis pigmentosa (RP). Adaptive techniques such as braille, digital and optical magnifiers, mobility training, cochlear implants, or other assistive listening devices are… read more here.
Keywords: gene drug; cell based; usher syndrome; review gene ... See more keywords
Effect Modification by Social Determinants of Pharmacogenetic Medication Interactions on 90-Day Hospital Readmissions within an Integrated U.S. Healthcare System
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12071145
Abstract: The present study builds on our prior work that demonstrated an association between pharmacogenetic interactions and 90-day readmission. In a substantially larger, more diverse study population of 19,999 adults tracked from 2010 through 2020 who… read more here.
Keywords: day; gene drug; drug interactions; social determinants ... See more keywords
Validation of Pharmacogenomic Interaction Probability (PIP) Scores in Predicting Drug–Gene, Drug–Drug–Gene, and Drug–Gene–Gene Interaction Risks in a Large Patient Population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12121972
Abstract: Utilizing pharmacogenomic (PGx) testing and integrating evidence-based guidance in drug therapy enables an improved treatment response and decreases the occurrence of adverse drug events. We conducted a retrospective analysis to validate the YouScript® PGx interaction… read more here.
Keywords: interaction; drug gene; gene drug; pip scores ... See more keywords