Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13295
Abstract: Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene‐edited mouse model that… read more here.
Keywords: vav1; edited mouse; gene edited; gene ... See more keywords
Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.20-0520
Abstract: Gene editing blood‐derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of edited cells following reinfusion. All… read more here.
Keywords: crispr cas9; edited cells; gene edited; gene ... See more keywords
Efficient production of transgene-free, gene-edited carrot plants via protoplast transformation.
Sign Up to like & getrecommendations! Published in 2022 at "Plant cell reports"
DOI: 10.1007/s00299-022-02830-9
Abstract: KEY MESSAGE We have developed and validated an efficient protocol for producing gene-edited carrot plants that do not result in the stable incorporation of foreign DNA in the edited plant's genome. We report here a… read more here.
Keywords: gene edited; edited carrot; carrot plants; transgene free ... See more keywords
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.02.002
Abstract: Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PCR sequencing… read more here.
Keywords: stem cells; cast seq; target; gene edited ... See more keywords
Into the multiverse of gene edited NK cell-based therapeutic strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.11.004
Abstract: In this issue of Cell Stem Cell, Woan et al., (2021) investigate the anti-cancer activity of triple gene edited iPSC-derived natural killer (NK) cells and demonstrate that expression of a modified CD16a and interleukin (IL)-15 receptor… read more here.
Keywords: gene edited; cell based; multiverse gene; cell ... See more keywords
Gene-Edited Crops: Towards a Harmonized Safety Assessment.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2018.11.014
Abstract: Gene editing and other innovative plant breeding techniques are transforming the field of crop biotechnology. Divergent national regulatory regimes worldwide apply to crops bred with these techniques. A plea is made for international harmonization of… read more here.
Keywords: edited crops; safety; gene edited; assessment ... See more keywords
Why were scientists silent over gene-edited babies?
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-00662-4
Abstract: To be successful as researchers, we must be able to think through the impacts of our work on society and speak up when necessary, says Natalie Kofler.To be successful as researchers, we must be able… read more here.
Keywords: edited babies; gene edited; scientists silent; silent gene ... See more keywords
The best spot to park a CAR
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3848
Abstract: 341 Cancer immunotherapy using T cells engineered to express chimeric antigen receptors (CARs) has achieved exciting results in patients with B-cell malignancies. In a recent report in Nature, Eyquem et al.1 sought to improve the… read more here.
Keywords: car cells; car expression; car; gene edited ... See more keywords
Simultaneous reprogramming and gene editing of human fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Nature protocols"
DOI: 10.1038/nprot.2018.007
Abstract: The utility of human induced pluripotent stem cells (iPSCs) is enhanced by an ability to precisely modify a chosen locus with minimal impact on the remaining genome. However, the derivation of gene-edited iPSCs typically involves… read more here.
Keywords: gene editing; human fibroblasts; gene edited; simultaneous reprogramming ... See more keywords
Managers’ attitudes toward gene-editing technology and companies’ R&D investment in gene-editing: the case of Chinese seed companies
Sign Up to like & getrecommendations! Published in 2022 at "GM Crops & Food"
DOI: 10.1080/21645698.2022.2140567
Abstract: ABSTRACT The Chinese government has issued a series of new policies to make it easier to industrialize gene-edited crops. However, whether technological advantages will eventually translate into industrial advantages and whether farmers will soon have… read more here.
Keywords: gene editing; seed companies; gene edited; seed ... See more keywords
Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117371
Abstract: Sickle cell disease (SCD) is an inherited blood disorder associated with a debilitating chronic illness. SCD is caused by a point mutation in the β-globin gene (HBB). A single nucleotide substitution converts glutamic acid to… read more here.
Keywords: scd hspcs; globin gene; target; gene edited ... See more keywords