Gene editing in liver diseases
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.14989
Abstract: The deliberate and precise modification of the host genome using engineered nucleases represents a groundbreaking advancement in modern medicine. Several clinical trials employing these approaches to address metabolic liver disorders have been initiated, with recent… read more here.
Keywords: gene editing; liver diseases; medicine; gene ... See more keywords
Two steps are better than one: improving gene editing to treat cancer
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13342
Abstract: Gene editing enables scientists to make precise changes to the genome of an organism using the cell’s own ability to repair damaged DNA using a supplied DNA template. In recent years, gene editing has been… read more here.
Keywords: dna; cancer; two steps; steps better ... See more keywords
The Delivery Challenge of Genome Editing in Human Epithelia.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100847
Abstract: Despite exciting advances in gene editing, their clinical translation is still hampered by the lack of delivery systems that can encapsulate and deliver gene editing tools like CRISPR-Cas9 or prime editors to the target side.… read more here.
Keywords: genome editing; gene editing; human epithelia; delivery ... See more keywords
A Versatile Nonviral Delivery System for Multiplex Gene-Editing in the Liver.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202003537
Abstract: Recent advances in CRISPR present attractive genome-editing toolsets for therapeutic strategies at the genetic level. Here, a liposome-coated mesoporous silica nanoparticle (lipoMSN) is reported as an effective CRISPR delivery system for multiplex gene-editing in the… read more here.
Keywords: gene editing; multiplex gene; delivery system; editing liver ... See more keywords
Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206433
Abstract: Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one‐step introduction of diacylation linkers and azide groups on the 2′‐OH of RNA is advance. Selected… read more here.
Keywords: gene editing; chemical control; guide rnas; diacylation ... See more keywords
Therapeutic In Vivo Gene Editing Achieved by a Hypercompact CRISPR‐Cas12f1 System Delivered with All‐in‐One Adeno‐Associated Virus
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308095
Abstract: CRISPR‐based gene therapies are making remarkable strides toward the clinic. But the large size of most widely used Cas endonucleases including Cas9 and Cas12a restricts their efficient delivery by the adeno‐associated virus (AAV) for in… read more here.
Keywords: system; gene; vivo gene; cas12f1 ... See more keywords
Gulo gene locus, a new gene editing locus for mammalian cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100493
Abstract: Transgene technology is valuable and helpful in many fields, including basic medical and biological research, biotechnology, and therapy. Recent advances in targeting technology accelerate the production of transgenic plants and animals and the application for… read more here.
Keywords: locus new; gene editing; gulo gene; gene locus ... See more keywords
Assessment of Miniature AsCas12f1 Variants for Gene Editing and Activation
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28978
Abstract: Miniature CRISPR/Cas systems possess delivery advantages for gene therapy. The type V‐F Cas12f1 from Acidibacillus sulfuroxidans is exceptionally compact (422 amino acids) and has been engineered by several studies as compact genome editing tools through… read more here.
Keywords: gene editing; activation; ascas12f1; miniature ... See more keywords
Application of Gene Editing in Triple‐Negative Breast Cancer Research
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70044
Abstract: With the rapid development of gene editing technology, its application in breast cancer has gradually become the focus of research. This article reviews the application of gene editing technology in the treatment of breast cancer,… read more here.
Keywords: editing technology; gene editing; breast cancer;
Chemical Modification and Transformation Strategies of Guide RNAs in CRISPR-Cas9 Gene Editing Systems.
Sign Up to like & getrecommendations! Published in 2021 at "ChemPlusChem"
DOI: 10.1002/cplu.202000785
Abstract: The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated protein 9) is a most powerful tool and has been widely used in gene editing and gene regulation since its discovery. However, wild-type CRISPR-Cas9 suffers from… read more here.
Keywords: guide rnas; gene editing; crispr cas9; gene ... See more keywords
Use of mitochondrial sequencing to detect gene doping in horses via gene editing and somatic cell nuclear transfer.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3267
Abstract: Gene editing and subsequent cloning techniques offer great potential not only in genetic disease correction in domestic animals, but also in livestock production by enhancement of desirable traits. The existence of the technology, however, leaves… read more here.
Keywords: mitochondrial sequencing; nuclear transfer; cell nuclear; somatic cell ... See more keywords