A meta‐analysis approach with filtering for identifying gene‐level gene–environment interactions
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22115
Abstract: There is a growing recognition that gene–environment interaction (G × E) plays a pivotal role in the development and progression of complex diseases. Despite a wealth of genetic data on various complex diseases/traits generated from… read more here.
Keywords: gene level; analysis; gene; gene environment ... See more keywords
Extended methods for gene–environment‐wide interaction scans in studies of admixed individuals with varying degrees of relationships
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22196
Abstract: The etiology of many complex diseases involves both environmental exposures and inherited genetic predisposition as well as interactions between them. Gene–environment‐wide interaction studies (GEWIS) provide a means to identify the interactions between genetic variation and… read more here.
Keywords: varying degrees; degrees relationships; environment wide; interaction ... See more keywords
Efficient gene–environment interaction tests for large biobank‐scale sequencing studies
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22351
Abstract: Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene–environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate… read more here.
Keywords: scale sequencing; sequencing studies; gene environment; environment interaction ... See more keywords
Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
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DOI: 10.1002/ijc.30859
Abstract: Investigating the most likely causal variants identified by fine‐mapping analyses may improve the power to detect gene–environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified by genetic fine‐scale mapping of susceptibility loci… read more here.
Keywords: cancer; environment interactions; gene environment; breast cancer ... See more keywords
Exposure enriched outcome dependent designs for longitudinal studies of gene-environment interaction.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7332
Abstract: Joint effects of genetic and environmental factors have been increasingly recognized in the development of many complex human diseases. Despite the popularity of case-control and case-only designs, longitudinal cohort studies that can capture time-varying outcome… read more here.
Keywords: longitudinal studies; exposure enriched; exposure; designs longitudinal ... See more keywords
Meta-analysis of gene-environment interaction exploiting gene-environment independence across multiple case-control studies.
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DOI: 10.1002/sim.7398
Abstract: Multiple papers have studied the use of gene-environment (G-E) independence to enhance power for testing gene-environment interaction in case-control studies. However, studies that evaluate the role of G-E independence in a meta-analysis framework are limited.… read more here.
Keywords: gene; independence; gene environment; meta analysis ... See more keywords
A unified method for rare variant analysis of gene-environment interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Statistics in medicine"
DOI: 10.1002/sim.8446
Abstract: Advanced technology in whole-genome sequencing has offered the opportunity to comprehensively investigate the genetic contribution, particularly rare variants, to complex traits. Several region-based tests have been developed to jointly model the marginal effect of rare… read more here.
Keywords: method; rare variants; environment interactions; gene ... See more keywords
Evocative gene‐environment correlation between genetic risk for schizophrenia and bullying victimization
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DOI: 10.1002/wps.20685
Abstract: World Psychiatry 18:3 October 2019 (four lessons); c) caring for me (three lessons); d) providing everyday care (five lessons); and e) dealing with changing behaviour (ten lessons). Each lesson presents information about a specific topic… read more here.
Keywords: environment correlation; correlation genetic; evocative gene; isupport ... See more keywords
Gene × Environment Interactions in the Development of Preschool Effortful Control, and Its Implications for Childhood Externalizing Behavior.
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DOI: 10.1007/s10519-021-10073-9
Abstract: This study examined the role of gene × environment interaction (G × E) in the development of effortful control (EC) and externalizing symptoms (EXT). Participants included 361 adopted children, and their Adoptive Parents (APs) and… read more here.
Keywords: gene environment; development; effortful control;
Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update
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DOI: 10.1007/s11920-018-0934-7
Abstract: Purpose of ReviewWe review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders.Recent FindingsResearch supports that susceptibility genes to… read more here.
Keywords: environment interactions; personality; gene environment; personality disorders ... See more keywords
Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications
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DOI: 10.1007/s11920-019-1065-5
Abstract: We identify the recent evidence for gene-by-environment interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as well as environmental exposures and how they interact to predict psychiatric disorders and… read more here.
Keywords: environment interaction; gene; gene environment; recent evidence ... See more keywords