Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2017.3458
Abstract: Importance Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology… read more here.
Keywords: biopsy specimens; expression; inflammation; gene expression ... See more keywords
MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14200
Abstract: Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including… read more here.
Keywords: mek erk; antiviral gene; interferon; gene expression ... See more keywords
STAT3‐mediated MLST8 gene expression regulates cap‐dependent translation in cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12735
Abstract: Signal transducer and activator of transcription 3 (STAT3) regulates cell growth, cell survival, angiogenesis, metastasis of cancer cells, and cancer immune evasion by regulating gene expression as a transcription factor. However, the effect of STAT3… read more here.
Keywords: gene expression; translation; expression; cancer cells ... See more keywords
Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13185
Abstract: In addition to mutations, epigenetic alterations are important contributors to malignant transformation and tumor progression. The aim of this work was to identify epigenetic events in which promoter or gene body DNA methylation induces gene… read more here.
Keywords: melanoma progression; progression; dna methylation; gene expression ... See more keywords
Analysis of the role of Frizzled 2 in different cancer types
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13111
Abstract: Frizzled 2 (FZD2) is an important receptor in the Wnt pathway, which is highly expressed in malignant tumors and helps regulate multiple tumor behaviors. Its expression level is related to prognosis. Here, bioinformatic analysis was… read more here.
Keywords: cancer types; analysis; gene expression; expression ... See more keywords
Tollip‐deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13423
Abstract: Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein aggregates and various signaling processes in mammalian models. To verify evolutionary conservation of these functions, we used CRISPR/Cas9 editing to construct… read more here.
Keywords: tollip deficient; display; development; gene expression ... See more keywords
New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13482
Abstract: The tetracycline repressor (tetR)‐regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line, which allows for the inducible expression… read more here.
Keywords: system; expression; gene expression; new regulators ... See more keywords
Collagen Stiffness and Architecture Regulate Fibrotic Gene Expression in Engineered Adipose Tissue
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900286
Abstract: Adipose tissue (AT) has a dynamic extracellular matrix (ECM) surrounding adipocytes that allows for remodeling during metabolic fluctuations. During the progression of obesity, AT has increased ECM deposition, stiffening, and remodeling, resulting in a pro‐fibrotic… read more here.
Keywords: collagen; stiffness architecture; expression; gene expression ... See more keywords
Simultaneous Single Cell Gene Expression and EGFR Mutation Analysis of Circulating Tumor Cells Reveals Distinct Phenotypes in NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000110
Abstract: While cancer cell populations are known to be highly heterogeneous within a tumor, the current gold standard of tumor profiling is through a tumor biopsy. These biopsies are invasive and prone to missing these clones… read more here.
Keywords: single cell; analysis; gene expression; cell ... See more keywords
Gene Expression has Distinct Associations with Brain Structure and Function in Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205486
Abstract: Major depressive disorder (MDD) is associated with structural and functional brain abnormalities. MDD as well as brain anatomy and function are influenced by genetic factors, but the role of gene expression remains unclear. Here, this… read more here.
Keywords: function; brain; gene expression; gene ... See more keywords
Shifts in gene expression profiles are associated with weak and strong Crassulacean acid metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of botany"
DOI: 10.1002/ajb2.1017
Abstract: PREMISE OF THE STUDY The relative ease of high throughput sequencing is facilitating comprehensive phylogenomic and gene expression studies, even for nonmodel groups. To date, however, these two approaches have not been merged; while phylogenomic… read more here.
Keywords: cam; metabolism; gene expression; expression ... See more keywords