Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13157
Abstract: Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and mutation acquisition are major impedances for tailoring personalized therapy. We collected blood and tumour tissue samples from 25… read more here.
Keywords: dna; mutations gene; gene fusions; gbm patients ... See more keywords
A trans‐omics assessment of gene–gene interaction in early‐stage NSCLC
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13345
Abstract: Epigenome‐wide gene–gene (G × G) interactions associated with non‐small‐cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three‐step analytic strategy to identify significant and robust G × G interactions that… read more here.
Keywords: interaction; step; gene gene; trans omics ... See more keywords
Association study of polymorphisms in the ABO gene and their gene‐gene interactions with ischemic stroke in Chinese population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22329
Abstract: To investigate the impact of 4 single nucleotide polymorphisms (SNPs) within ABO gene and their gene‐gene interactions on ischemic stroke (IS) susceptibility in Chinese Han population. read more here.
Keywords: interactions ischemic; gene interactions; ischemic stroke; abo gene ... See more keywords
Omnibus testing approach for gene‐based gene‐gene interaction
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9389
Abstract: Genetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the… read more here.
Keywords: based gene; interaction; gene gene; gene interaction ... See more keywords
Gene- gene interaction between CYP2J2 and PPAR -γ gene on late-onset Alzheimer’s disease in the eastern Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.07.010
Abstract: Aims: To investigate the impact of PPAR ‐&ggr; and CYP2J2 gene single nucleotide polymorphisms (SNPs) and gene‐ gene interactions on late‐onset Alzheimer's disease (LOAD) risk in Chinese Han population. Methods: A total of 880 participants… read more here.
Keywords: cyp2j2 ppar; load; gene gene; gene ... See more keywords
Gene-gene and gene-lifestyle interactions of AKAP11, KCNMA1, PUM1, SPTBN1, and EPDR1 on osteoporosis risk in middle-aged adults.
Sign Up to like & getrecommendations! Published in 2020 at "Nutrition"
DOI: 10.1016/j.nut.2020.110859
Abstract: OBJECTIVES Osteoporosis is associated with genetic and environmental factors. The aim of this article was to determine how the polygenic risk scores (PRS) of genetic variants that affect osteoporosis and its related signaling interact with… read more here.
Keywords: risk; prsbm; group; gene gene ... See more keywords
Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0387-5
Abstract: A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations.… read more here.
Keywords: gene interactions; gene gene; gene; environment gene ... See more keywords
Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Data"
DOI: 10.1038/sdata.2018.284
Abstract: Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and… read more here.
Keywords: gene gene; non small; type; gene ... See more keywords
Impact of CRP gene and additional gene–smoking interaction on ischemic stroke in a Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Research"
DOI: 10.1080/01616412.2017.1297905
Abstract: Abstract Aims: To investigate the association of C-reactive protein (CRP) gene single nucleotide polymorphisms (SNPs), additional gene–gene, and gene–smoking interaction with ischemic stroke (IS) risk. Methods: Logistic regression is performed to investigate association between SNPs… read more here.
Keywords: crp gene; risk; gene gene; interaction ... See more keywords
P2X3-P2X7 SNPs and gene-gene and gene-environment interactions on pediatric asthma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2155184
Abstract: Abstract Background To investigate the relationship between polymorphisms of P2X3, P2X7 genes and environment interaction with susceptibility of childhood asthma. Methods We conducted a matched case-control study with 170 cases and 175 healthy controls. The… read more here.
Keywords: environment; gene gene; p2x3; asthma ... See more keywords
DEGGs: an R package with shiny app for the identification of differentially expressed gene–gene interactions in high-throughput sequencing data
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad192
Abstract: Abstract Summary The discovery of differential gene–gene correlations across phenotypical groups can help identify the activation/deactivation of critical biological processes underlying specific conditions. The presented R package, provided with a count and design matrix, extract… read more here.
Keywords: package shiny; gene gene; shiny app; deggs package ... See more keywords