Why are there hotspot mutations in the TP53 gene in human cancers?
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.180
Abstract: The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that span ~190 different codons localized in the DNA-binding domain of the gene and protein.… read more here.
Keywords: human cancers; dna; hotspot mutations; gene ... See more keywords
The role of KMT2 gene in human tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-447
Abstract: Histone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2… read more here.
Keywords: human tumors; gene human; kmt2 gene; role kmt2 ... See more keywords
Sequence Alignment between TRIM33 Gene and Human Noncoding RNAs: A Potential Explanation for Paraneoplastic Dermatomyositis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm14060628
Abstract: Background: This computational analysis investigated sequence complementarities between the TRIM33 gene and human noncoding (nc)RNAs and characterized their interactions in the context of paraneoplastic dermatomyositis. Methods: TRIM33 FASTA sequence (NCBI Reference Sequence: NC_000001.11) was used… read more here.
Keywords: trim33 gene; sequence; gene human; dermatomyositis ... See more keywords