Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth
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DOI: 10.2337/db19-1106
Abstract: Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated remains unknown.… read more here.
Keywords: mutant ins; gene induced; induced diabetes; diabetes youth ... See more keywords