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   Articles with "gene interaction" as a keyword



Gene interaction analysis of psoriasis in Chinese Han population

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recommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.1858

Abstract: Psoriasis is a chronic immune‐mediated inflammatory skin disease characterized by excessive proliferation of keratinocytes. It has a strong genetic predisposition; gene‐gene interactions are important genetic models for common diseases. In this study, we explore pair‐wise… read more here.

Keywords: analysis psoriasis; gene interaction; psoriasis chinese; gene ... See more keywords

Omnibus testing approach for gene‐based gene‐gene interaction

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recommendations! Published in 2022 at "Statistics in Medicine"

DOI: 10.1002/sim.9389

Abstract: Genetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the… read more here.

Keywords: based gene; interaction; gene gene; gene interaction ... See more keywords

46 THE POLYGENIC EPISTASIS RISK SCORE DEMONSTRATES SIGNIFICANT ROLE OF GENE INTERACTION IN BIPOLAR DISORDER

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recommendations! Published in 2019 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2017.08.047

Abstract: Background Gene-gene interaction occurs when the association of one locus to a phenotype depends on the genotype at a different locus. GWAS has made possible the discovery of dozens of genes for psychiatric illnesses generally… read more here.

Keywords: risk score; gene; gene interaction; interaction ... See more keywords

Transcriptome-conditioned molecule generation via gene interaction-aware fragment modeling with a GPT-based architecture

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-17439-7

Abstract: Phenotype-driven drug discovery leverages cellular responses to guide the design of therapeutic molecules. Recent advancements in transcriptomics have provided extensive datasets describing how gene expression changes in response to various chemical stimuli, presenting an opportunity… read more here.

Keywords: architecture; generation; gene interaction; molecule generation ... See more keywords

Two-stage-vote ensemble framework based on integration of mutation data and gene interaction network for uncovering driver genes

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recommendations! Published in 2022 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbab429

Abstract: Identifying driver genes, exactly from massive genes with mutations, promotes accurate diagnosis and treatment of cancer. In recent years, a lot of works about uncovering driver genes based on integration of mutation data and gene… read more here.

Keywords: gene interaction; mutation; vote; driver ... See more keywords

Integration of gene interaction information into a reweighted Lasso-Cox model for accurate survival prediction

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recommendations! Published in 2021 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaa1046

Abstract: MOTIVATION Accurately predicting the risk of cancer patients is a central challenge for clinical cancer research. For high-dimensional gene expression data, Cox proportional hazard model with the least absolute shrinkage and selection operator for variable… read more here.

Keywords: cox model; model; lasso cox; gene interaction ... See more keywords

Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.

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recommendations! Published in 2017 at "IEEE/ACM transactions on computational biology and bioinformatics"

DOI: 10.1109/tcbb.2015.2511758

Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for cancer patients, the heterogeneous multi-omics data should be integrated harmoniously, which can… read more here.

Keywords: interaction regularized; gene interaction; cancer; gene ... See more keywords

A Secure High-Order Gene Interaction Detecting Method for Infectious Diseases

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/4471736

Abstract: Infectious diseases pose a serious threat to human life, the Genome Wide Association Studies (GWAS) can analyze susceptibility genes of infectious diseases from the genetic level and carry out targeted prevention and treatment. The susceptibility… read more here.

Keywords: infectious diseases; gene interaction; high order; detection ... See more keywords

Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data

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recommendations! Published in 2024 at "BMC Bioinformatics"

DOI: 10.1186/s12859-024-05946-9

Abstract: Gene interaction networks are graphs in which nodes represent genes and edges represent functional interactions between them. These interactions can be at multiple levels, for instance, gene regulation, protein-protein interaction, or metabolic pathways. To analyse… read more here.

Keywords: interaction networks; gene interaction; shrinkage; rna sequencing ... See more keywords

Poor statistical power in population-based association study of gene interaction

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recommendations! Published in 2024 at "BMC Medical Genomics"

DOI: 10.1186/s12920-024-01884-w

Abstract: Background Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype. In the genetic association analysis of complex traits, nevertheless,… read more here.

Keywords: gene interaction; association; interaction; gene ... See more keywords

Disruptions in gene interaction networks abolish host susceptibility to Trichostrongylus colubriformis infections in sheep

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recommendations! Published in 2025 at "PLOS Neglected Tropical Diseases"

DOI: 10.1371/journal.pntd.0013399

Abstract: The roundworm Trichostrongylus colubriformis is one of the most important parasites in sheep, impairing feed conversion and reducing growth. However, the molecular mechanism of host resistance to this important species remains elusive. In this study,… read more here.

Keywords: host; interaction networks; gene interaction; gene ... See more keywords