Gene interaction analysis of psoriasis in Chinese Han population
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1858
Abstract: Psoriasis is a chronic immune‐mediated inflammatory skin disease characterized by excessive proliferation of keratinocytes. It has a strong genetic predisposition; gene‐gene interactions are important genetic models for common diseases. In this study, we explore pair‐wise… read more here.
Keywords: analysis psoriasis; gene interaction; psoriasis chinese; gene ... See more keywords
Omnibus testing approach for gene‐based gene‐gene interaction
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9389
Abstract: Genetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the… read more here.
Keywords: based gene; interaction; gene gene; gene interaction ... See more keywords
46 THE POLYGENIC EPISTASIS RISK SCORE DEMONSTRATES SIGNIFICANT ROLE OF GENE INTERACTION IN BIPOLAR DISORDER
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.047
Abstract: Background Gene-gene interaction occurs when the association of one locus to a phenotype depends on the genotype at a different locus. GWAS has made possible the discovery of dozens of genes for psychiatric illnesses generally… read more here.
Keywords: risk score; gene; gene interaction; interaction ... See more keywords
Two-stage-vote ensemble framework based on integration of mutation data and gene interaction network for uncovering driver genes
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab429
Abstract: Identifying driver genes, exactly from massive genes with mutations, promotes accurate diagnosis and treatment of cancer. In recent years, a lot of works about uncovering driver genes based on integration of mutation data and gene… read more here.
Keywords: gene interaction; mutation; vote; driver ... See more keywords
Integration of gene interaction information into a reweighted Lasso-Cox model for accurate survival prediction
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa1046
Abstract: MOTIVATION Accurately predicting the risk of cancer patients is a central challenge for clinical cancer research. For high-dimensional gene expression data, Cox proportional hazard model with the least absolute shrinkage and selection operator for variable… read more here.
Keywords: cox model; model; lasso cox; gene interaction ... See more keywords
Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.
Sign Up to like & getrecommendations! Published in 2017 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2015.2511758
Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for cancer patients, the heterogeneous multi-omics data should be integrated harmoniously, which can… read more here.
Keywords: interaction regularized; gene interaction; cancer; gene ... See more keywords
A Secure High-Order Gene Interaction Detecting Method for Infectious Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/4471736
Abstract: Infectious diseases pose a serious threat to human life, the Genome Wide Association Studies (GWAS) can analyze susceptibility genes of infectious diseases from the genetic level and carry out targeted prevention and treatment. The susceptibility… read more here.
Keywords: infectious diseases; gene interaction; high order; detection ... See more keywords
Prediction of Genetic Factors of Hyperthyroidism Based on Gene Interaction Network
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.700355
Abstract: The number of hyperthyroidism patients is increasing these years. As a disease that can lead to cardiovascular disease, it brings great potential health risks to humans. Since hyperthyroidism can induce the occurrence of many diseases,… read more here.
Keywords: interaction network; hyperthyroidism; gene; gene interaction ... See more keywords