Association study of polymorphisms in the ABO gene and their gene‐gene interactions with ischemic stroke in Chinese population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22329
Abstract: To investigate the impact of 4 single nucleotide polymorphisms (SNPs) within ABO gene and their gene‐gene interactions on ischemic stroke (IS) susceptibility in Chinese Han population. read more here.
Keywords: interactions ischemic; gene interactions; ischemic stroke; abo gene ... See more keywords
Predicting Potential Drug-Drug-Gene Interactions in a Population of Individuals Utilizing a Community-Based Pharmacy
Sign Up to like & getrecommendations! Published in 2022 at "CNS Spectrums"
DOI: 10.1017/s1092852922000372
Abstract: Abstract Introduction Adverse drug reactions (ADRs) are associated with increased morbidity, mortality, and resource utilization. Drug interactions (DDIs) are among the most common causes of ADRs, and estimates have cited that up to 22% of… read more here.
Keywords: potential drug; drug gene; drug drug; gene interactions ... See more keywords
Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0387-5
Abstract: A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations.… read more here.
Keywords: gene interactions; gene gene; gene; environment gene ... See more keywords
Identifying the prevalence of clinically actionable drug‐gene interactions in a health system biorepository to guide pharmacogenetics implementation services
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13449
Abstract: Understanding patterns of drug‐gene interactions (DGIs) is important for advancing the clinical implementation of pharmacogenetics (PGx) into routine practice. Prior studies have estimated the prevalence of DGIs, but few have confirmed DGIs in patients with… read more here.
Keywords: prevalence; drug gene; implementation; gene interactions ... See more keywords
HisCoM-GGI: Hierarchical structural component analysis of gene-gene interactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720018400267
Abstract: Although genome-wide association studies (GWAS) have successfully identified thousands of single nucleotide polymorphisms (SNPs) associated with common diseases, these observations are limited for fully explaining "missing heritability". Determining gene-gene interactions (GGI) are one possible avenue… read more here.
Keywords: hiscom ggi; gene interactions; analysis; gene gene ... See more keywords
Eigen-Epistasis for detecting gene-gene interactions
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1488-0
Abstract: BackgroundA large amount of research has been devoted to the detection and investigation of epistatic interactions in genome-wide association studies (GWASs). Most of the literature focuses on low-order interactions between single-nucleotide polymorphisms (SNPs) with significant… read more here.
Keywords: gene interactions; epistasis detecting; gene gene; gene ... See more keywords
Transient crosslinking kinetics optimize gene cluster interactions
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007124
Abstract: Our understanding of how chromosomes structurally organize and dynamically interact has been revolutionized through the lens of long-chain polymer physics. Major protein contributors to chromosome structure and dynamics are condensin and cohesin that stochastically generate… read more here.
Keywords: gene interactions; crosslinking kinetics; kinetics optimize; transient crosslinking ... See more keywords
Drug–Drug–Gene Interactions in Cardiovascular Medicine
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DOI: 10.2147/pgpm.s338601
Abstract: Abstract Cardiovascular disease remains a leading cause of both morbidity and mortality worldwide. It is widely accepted that both concomitant medications (drug–drug interactions, DDIs) and genomic factors (drug–gene interactions, DGIs) can influence cardiovascular drug-related efficacy… read more here.
Keywords: drug gene; drug drug; gene interactions; drug ... See more keywords
How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia
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DOI: 10.3390/genes13061040
Abstract: Schizophrenia is a highly heritable polygenic psychiatric disorder. Characterization of its genetic architecture may lead to a better understanding of the overall burden of risk variants and how they determine susceptibility to disease. A major… read more here.
Keywords: risk allele; gene interactions; risk; genetic architecture ... See more keywords