A meta‐analysis approach with filtering for identifying gene‐level gene–environment interactions
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22115
Abstract: There is a growing recognition that gene–environment interaction (G × E) plays a pivotal role in the development and progression of complex diseases. Despite a wealth of genetic data on various complex diseases/traits generated from… read more here.
Keywords: gene level; analysis; gene; gene environment ... See more keywords
Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.983
Abstract: Evidence suggests that liability for suicide behavior is heritable; additionally, suicide has been partly related to other psychiatric disorders. Nevertheless, most of the information reported so far address Caucasian and Asian individuals. Hence, our aim… read more here.
Keywords: association; gene level; suicide attempt;
Identification of pleiotropy at the gene level between psychiatric disorders and related traits
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01530-4
Abstract: Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) have recently provided evidence for… read more here.
Keywords: gene level; disorders related; level; pleiotropy gene ... See more keywords
Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23029-8
Abstract: We propose microbiome disease “architectures”: linking >1 million microbial features (species, pathways, and genes) to 7 host phenotypes from 13 cohorts using a pipeline designed to identify associations that are robust to analytical model choice.… read more here.
Keywords: gene level; level metagenomic; disease; diagnostic indicators ... See more keywords
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1231-2
Abstract: Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify… read more here.
Keywords: gene level; exome sequencing; type diabetes; rare variants ... See more keywords
GeVIR is a continuous gene-level metric that uses variant distribution patterns to prioritize disease candidate genes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Genetics"
DOI: 10.1038/s41588-019-0560-2
Abstract: With large-scale population sequencing projects gathering pace, there is a need for strategies that advance disease gene prioritization 1 , 2 . Metrics that provide information about a gene and its ability to tolerate protein-altering… read more here.
Keywords: gene level; continuous gene; disease; level metric ... See more keywords
Genome-Wide Linkage-Disequilibrium Mapping to the Candidate Gene Level in Melon (Cucumis melo)
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09987-4
Abstract: Cucumis melo is highly diverse for fruit traits providing wide breeding and genetic research opportunities, including genome-wide association (GWA) analysis. We used a collection of 177 accessions representing the two C. melo subspecies and 11… read more here.
Keywords: genome wide; gene level; melon; cucumis melo ... See more keywords
A comprehensive comparison of residue-level methylation levels with the regression-based gene-level methylation estimations by ReGear
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa253
Abstract: MOTIVATION DNA methylation is a biological process impacting the gene functions without changing the underlying DNA sequence. The DNA methylation machinery usually attaches methyl groups to some specific cytosine residues, which modify the chromatin architectures.… read more here.
Keywords: gene level; methylation; level methylation; gene ... See more keywords
Contrasting gene‐level signatures of selection with reproductive fitness
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Ecology"
DOI: 10.1111/mec.16329
Abstract: Selection leaves signatures in the DNA sequence of genes, with many test statistics devised to detect its action. While these statistics are frequently used to support hypotheses about the adaptive significance of particular genes, the… read more here.
Keywords: level signatures; gene level; gene; fitness ... See more keywords
OR05-1 Genetic Discovery and Translational Decision Support from Exome Sequencing of 45,231 Type 2 Diabetes Cases and Controls from Five Ancestries
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-or05-1
Abstract: Abstract Analysis of human exome sequences, the protein-coding regions of genomes, has the potential to identify variation in genes relevant to disease for expedited clinical and therapeutic translation. Here we present results from a massive-scale… read more here.
Keywords: exome sequencing; type diabetes; gene; gene level ... See more keywords
Elevated IP-10 at the Protein and Gene Level Associates With Pulmonary TB
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.908144
Abstract: There is an urgent need for accurate and sensitive diagnostic tools that can overcome the current challenge to distinguish individuals with latent tuberculosis infection (LTBI) from individuals with active tuberculosis (TB). Recent literature has suggested… read more here.
Keywords: gene level; healthy ltbi; level; protein gene ... See more keywords