Gulo gene locus, a new gene editing locus for mammalian cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100493
Abstract: Transgene technology is valuable and helpful in many fields, including basic medical and biological research, biotechnology, and therapy. Recent advances in targeting technology accelerate the production of transgenic plants and animals and the application for… read more here.
Keywords: locus new; gene editing; gulo gene; gene locus ... See more keywords
Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population.
Sign Up to like & getrecommendations! Published in 2020 at "Genomics"
DOI: 10.1016/j.ygeno.2020.02.002
Abstract: To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885,… read more here.
Keywords: risk; gene locus; eoc; igf2 h19 ... See more keywords
Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006001
Abstract: Key Points A paucity of follicular CD8+ T cells in LN germinal centers contributes to HIV persistence during cART. CXCR5 expression in human CD8+ T cells is tightly regulated by epigenetic mechanisms. read more here.
Keywords: cd8 cells; gene locus; locus limits; cxcr5 gene ... See more keywords
Lamin A/C modulates spatial organization and function of the Hsp70 gene locus via Nuclear Myosin I (NM1).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.236265
Abstract: Nuclear structure-function is tightly regulated, especially during heat shock. Typically, heat shock activates molecular chaperones that prevent protein misfolding and preserve genome integrity. However, the molecular mechanisms that regulate nuclear structure-function relationships during heat shock… read more here.
Keywords: heat shock; hsp70 gene; shock; gene locus ... See more keywords
Nup93 and CTCF modulate spatiotemporal dynamics and function of the HOXA gene locus during differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.259307
Abstract: Nucleoporins regulate nuclear transport and are also involved in DNA damage, repair, cell cycle, chromatin organization, and gene expression. Here, we studied the role of nucleoporin Nup93 and the chromatin organizer CTCF in regulating HOXA… read more here.
Keywords: gene locus; hoxa gene; nup93 ctcf; differentiation ... See more keywords
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1143067
Abstract: Background Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by genetic and environmental factors. T2DM is associated with long-term complications that… read more here.
Keywords: gene locus; x10; snp; type diabetes ... See more keywords
Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.630933
Abstract: In tuberous sclerosis complex (TSC), Tsc2 mutations are associated with more severe disease manifestations than Tsc1 mutations and the role of extracellular vesicles (EVs) in this context is not yet studied. We report a comparative… read more here.
Keywords: extracellular vesicles; locus disruption; gene locus; tsc gene ... See more keywords