Examination of gene loss in the DNA mismatch repair pathway and its mutational consequences in a fungal phylum.
Sign Up to like & getrecommendations! Published in 2021 at "Genome biology and evolution"
DOI: 10.1093/gbe/evab219
Abstract: The DNA mismatch repair (MMR) pathway corrects mismatched bases produced during DNA replication and is highly conserved across the tree of life, reflecting its fundamental importance for genome integrity. Loss of function in one or… read more here.
Keywords: dna mismatch; mmr pathway; mismatch repair; gene loss ... See more keywords
Rapid shifts in mitochondrial tRNA import in a plant lineage with extensive mitochondrial tRNA gene loss.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msab255
Abstract: In most eukaryotes, transfer RNAs (tRNAs) are one of the very few classes of genes remaining in the mitochondrial genome, but some mitochondria have lost these vestiges of their prokaryotic ancestry. Sequencing of mitogenomes from… read more here.
Keywords: trna; trna gene; gene loss; mitochondrial trna ... See more keywords
A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac118
Abstract: Abstract Whole-genome duplications (WGDs) have occurred in many eukaryotic lineages. However, the underlying evolutionary forces and molecular mechanisms responsible for the long-term retention of gene duplicates created by WGDs are not well understood. We employ… read more here.
Keywords: loss; loss following; gene loss; whole genome ... See more keywords
Dynamics of Gene Loss following Ancient Whole-Genome Duplication in the Cryptic Paramecium Complex
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad107
Abstract: Abstract Whole-genome duplications (WGDs) have shaped the gene repertoire of many eukaryotic lineages. The redundancy created by WGDs typically results in a phase of massive gene loss. However, some WGD–derived paralogs are maintained over long… read more here.
Keywords: paramecium; genome; gene loss; gene ... See more keywords
Purifying and Positive Selection Influence Patterns of Gene Loss and Gene Expression in the Evolution of a Plant Sex Chromosome System
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx064
Abstract: Sex chromosomes are unique regions of the genome, with a host of properties that distinguish them from autosomes and from each other. Although there is extensive theory describing sex chromosome formation and subsequent degeneration of… read more here.
Keywords: sex; gene; degeneration; chromosome ... See more keywords
Gene Loss and Acquisition in Lineages of Pseudomonas aeruginosa Evolving in Cystic Fibrosis Patient Airways
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02359-20
Abstract: Bacterial airway infections, predominantly caused by P. aeruginosa, are a major cause of mortality and morbidity of CF patients. While short insertions and deletions as well as point mutations occurring during infection are well studied,… read more here.
Keywords: gene loss; loss; host; loss acquisition ... See more keywords
Rechallenge with erlotinib in osimertinib-resistant lung adenocarcinoma mediated by driver gene loss: a case report.
Sign Up to like & getrecommendations! Published in 2020 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2020.01.10
Abstract: The efficacy and safety of osimertinib have been demonstrated in several clinical trials; however, acquired resistance is an inevitable problem associated with most targeted drugs. Based on previous findings, the mechanism of osimertinib resistance is… read more here.
Keywords: driver gene; resistance; gene loss; mediated driver ... See more keywords
Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13112131
Abstract: Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5). Their activation establishes an antiviral state by… read more here.
Keywords: loss; mda5 gene; loss birds; gene ... See more keywords
Plastome of the mycoheterotrophic eudicot Exacum paucisquama (Gentianaceae) exhibits extensive gene loss and a highly expanded inverted repeat region
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ"
DOI: 10.7717/peerj.9157
Abstract: Mycoheterotrophic plants are highly specialized species able to acquire organic carbon from symbiotic fungi, with relaxed dependence on photosynthesis for carbon fixation. The relaxation of the functional constraint of photosynthesis and thereby the relaxed selective… read more here.
Keywords: eudicot exacum; paucisquama; loss highly; gene ... See more keywords