Identification of a New m6A Regulator-Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Mediators of Inflammation"
DOI: 10.1155/2023/5565054
Abstract: Pancreatic cancer (PC) is a malignant tumor of the digestive system that has a bad prognosis. N6-methyladenosine (m6A) is involved in a wide variety of biological activities due to the fact that it is the… read more here.
Keywords: methylation; methylation signature; prognosis; gene methylation ... See more keywords
Breast Hormone Concentrations in Random Fine-Needle Aspirates of Healthy Women Associate with Cytological Atypia and Gene Methylation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-17-0323
Abstract: Sex steroid hormones contribute to breast cancer development, but data on concentrations of these within breast tissue are limited. We performed simultaneous multiparameter measurement of breast sex steroids, breast epithelial cytology, and DNA methylation in… read more here.
Keywords: methylation; random fine; breast; fine needle ... See more keywords
Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-00940-7
Abstract: Although most commonly benign, neurofibromas (NFs) can have devastating functional and cosmetic effects in addition to the possibility of malignant transformation. In orbitofacial neurofibromatosis type 1, NFs may cause progressive, disfiguring tumors of the lid,… read more here.
Keywords: orbitofacial nfs; methylation; family; nfs ... See more keywords
MGMT promoter gene methylation and neurological scale improvement in glioma: a cohort study
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.51213.1
Abstract: Background : Glioma is one of the most common primary brain tumours and conveys a dismal prognosis despite aggressive treatment. Several biomarkers have been studied in the hope of yielding better diagnostic accuracy and improving patient management. Besides survival, functional and neurological disability are concerns that have no lesser importance. In 2017, a disease-specific assessment… read more here.
Keywords: gene methylation; mgmt promoter; improvement; promoter gene ... See more keywords
Investigating gene methylation signatures for fetal intolerance prediction
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DOI: 10.1371/journal.pone.0250032
Abstract: Pregnancy is a complicated and long procedure during one or more offspring development inside a woman. A short period of oxygen shortage after birth is quite normal for most babies and does not threaten their… read more here.
Keywords: fetal intolerance; gene methylation; prediction; intolerance ... See more keywords
Gene methylation as a powerful biomarker for detection and screening of non-small cell lung cancer in blood
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15919
Abstract: DNA methylation has been reported to become a potential powerful tool for cancer detection and diagnosis. However, the possibilities for the application of blood-based gene methylation as a biomarker for non-small cell lung cancer (NSCLC)… read more here.
Keywords: methylation; detection; detection screening; biomarker ... See more keywords
Gene methylation biomarkers in sputum as a classifier for lung cancer risk
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19255
Abstract: CT screening for lung cancer reduces mortality, but will cost Medicare ∼2 billion dollars due in part to high false positive rates. Molecular biomarkers could augment current risk stratification used to select smokers for screening.… read more here.
Keywords: methylation; risk; lung cancer; cancer ... See more keywords
Glutamic Acid Decarboxylase 1 Gene Methylation and Panic Disorder Severity: Making the Connection by Brain Gray Matter Volume
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.853613
Abstract: Objective This study aimed to test the hypothesis that the relationship between glutamic acid decarboxylase (GAD) 1 gene methylation and severity of clinical symptoms of panic disorder (PD) is mediated by the effect of GAD1… read more here.
Keywords: methylation; severity; gray matter; gene methylation ... See more keywords
The Intersection between Oral Microbiota, Host Gene Methylation and Patient Outcomes in Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113425
Abstract: Simple Summary Recently, there has been increased recognition of an association between the bacterial microbiome and cancer. In this study, we characterized the non-HPV head and neck squamous cell carcinoma (HNSCC) microbiome. We found a… read more here.
Keywords: gene methylation; hnscc; gene; host gene ... See more keywords
Extracellular Spermine Activates DNA Methyltransferase 3A and 3B
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20051254
Abstract: We first demonstrated that long-term increased polyamine (spermine, spermidine, putrescine) intake elevated blood spermine levels in mice and humans, and lifelong consumption of polyamine-rich chow inhibited aging-associated increase in aberrant DNA methylation, inhibited aging-associated pathological… read more here.
Keywords: spermine; methylation; extracellular spermine; aging associated ... See more keywords
Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with DNMT1 Gene Methylation Levels
Sign Up to like & getrecommendations! Published in 2019 at "Metabolites"
DOI: 10.3390/metabo9120298
Abstract: DNA methyltransferase 1 (DNMT1) is responsible for the maintenance of DNA methylation patterns during cell division. Several human diseases are characterized by impaired DNMT1 gene methylation, but less is known about the factors that regulate… read more here.
Keywords: gene methylation; methylation; dnmt1 gene; methylation levels ... See more keywords