Gene modification therapies for hereditary diseases in the fetus
Sign Up to like & getrecommendations! Published in 2023 at "Prenatal Diagnosis"
DOI: 10.1002/pd.6347
Abstract: Proof‐of‐principle disease models have demonstrated the feasibility of an intrauterine gene modification therapy (in utero gene therapy (IUGT)) approach to hereditary diseases as diverse as coagulation disorders, haemoglobinopathies, neurogenetic disorders, congenital metabolic, and pulmonary diseases.… read more here.
Keywords: gene modification; pathology; modification therapies; gene ... See more keywords
Ethical considerations of preconception and prenatal gene modification in the embryo and fetus.
Sign Up to like & getrecommendations! Published in 2021 at "Human reproduction"
DOI: 10.1093/humrep/deab222
Abstract: The National Academies of Sciences and Medicine 2020 consensus statement advocates the reinstatement of research in preconception heritable human genome editing (HHGE), despite the ethical concerns that have been voiced about interventions in the germline,… read more here.
Keywords: considerations preconception; gene; gene modification; ethical considerations ... See more keywords
TMOD-20. A SWINE MODEL OF GLIOBLASTOMA INDUCED BY SOMATIC GENE MODIFICATION
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.971
Abstract: Glioblastoma (GBM) is the most common and malignant primary brain tumor. Novel therapeutic development for GBM is needed since the standard of care universally fails to cure patients and the five-year survival rate remains below… read more here.
Keywords: glioblastoma; gbm; gene modification; model ... See more keywords
A novel mouse model for an inducible gene modification in the renal thick ascending limb
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Physiology - Renal Physiology"
DOI: 10.1152/ajprenal.00250.2022
Abstract: The thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant… read more here.
Keywords: mouse; gene modification; thick ascending; physiology ... See more keywords
Gene Editing Versus Gene Modification: Awareness, Attitudes and Behavioral Intentions of Lithuanian Consumers, Producers, and Farmers
Sign Up to like & getrecommendations! Published in 2021 at "Chemical engineering transactions"
DOI: 10.3303/cet2187073
Abstract: Gene editing (GE) and gene modification (GM) technologies demonstrate noticeable differences. GE technologies introduce changes in DNA, which are intrinsic to the species, while GM technologies incorporate changes from foreign species. The potential benefits of… read more here.
Keywords: awareness; gene editing; gene modification; food ... See more keywords
Effects of SCN9A gene modification on Na+ channel and the expression of nerve growth factor in a rat model of diarrhea‑predominant irritable bowel syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8061
Abstract: The aim of the present study was to identify whether the sodium voltage-gated channel alpha subunit 9 (SCN9A) gene modification is a potential treatment for diarrhea‑predominant irritable bowel syndrome (D‑IBS), via regulating the Na+ channel and… read more here.
Keywords: scn9a gene; gene modification; expression; gene ... See more keywords