Pan‐Cancer Single‐Cell Transcriptomic Analysis Reveals Divergent Expression of Embryonic Proangiogenesis Gene Modules in Tumorigenesis
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DOI: 10.1002/cam4.70373
Abstract: Angiogenesis is indispensable for the sustained survival and progression of both embryonic development and tumorigenesis. This intricate process is tightly regulated by a multitude of pro‐angiogenic genes. The presence of gene modules facilitating angiogenesis has… read more here.
Keywords: cancer single; gene modules; pan cancer; gene ... See more keywords
Multi-scale geometric network analysis identifies melanoma immunotherapy response gene modules
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DOI: 10.1038/s41598-024-56459-7
Abstract: Melanoma response to immune-modulating therapy remains incompletely characterized at the molecular level. In this study, we assess melanoma immunotherapy response using a multi-scale network approach to identify gene modules with coordinated gene expression in response… read more here.
Keywords: response; gene modules; multi scale; network ... See more keywords
Correlated gene modules uncovered by high-precision single-cell transcriptomics
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206938119
Abstract: Significance In a human cell, transcription of a particular gene invariably fluctuates with time, and the fluctuations of several transcripts can be correlated because they are regulated by the same transcription factor. By developing a… read more here.
Keywords: correlated gene; cell; gene modules; single cell ... See more keywords
Multi-level attention graph neural network based on co-expression gene modules for disease diagnosis and prognosis
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DOI: 10.1093/bioinformatics/btac088
Abstract: MOTIVATION Advanced deep learning techniques have been widely applied in disease diagnosis and prognosis with clinical omics, especially gene expression data. In the regulation of biological processes and disease progression, genes often work interactively rather… read more here.
Keywords: diagnosis prognosis; multi level; gene modules; graph ... See more keywords
Weighted Gene Correlation Network Analysis (WGCNA) of Arabidopsis Somatic Embryogenesis (SE) and Identification of Key Gene Modules to Uncover SE-Associated Hub Genes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Genomics"
DOI: 10.1155/2022/7471063
Abstract: Somatic embryogenesis (SE), which occurs naturally in many plant species, serves as a model to elucidate cellular and molecular mechanisms of embryo patterning in plants. Decoding the regulatory landscape of SE is essential for its… read more here.
Keywords: hub genes; embryogenesis; gene modules; analysis ... See more keywords
Trajectory-centric framework TrajAtlas reveals multi-scale differentiation heterogeneity among cells, genes, and gene modules in osteogenesis
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011319
Abstract: Osteoblasts, the key cells responsible for bone formation and the maintenance of skeletal integrity, originate from a diverse array of progenitor cells. However, the mechanisms underlying osteoblast differentiation from these multiple osteoprogenitors remain poorly understood.… read more here.
Keywords: differentiation; cells genes; framework; genes gene ... See more keywords
Co-expression analysis reveals key gene modules of bone metastases
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/13780
Abstract: Background: Bone metastases are a cancer which causes great injury to people world-widely. Although gene expression analyses had been performed previously, systemic co-expression analysis for this cancer is still lacking. Methods: Here, we analyzed the… read more here.
Keywords: gene modules; bone metastases; expression; expression analysis ... See more keywords
Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s163891
Abstract: Introduction Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA) and gene modules or… read more here.
Keywords: gene modules; pathological stage; mirna gene; cancer ... See more keywords
The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10020121
Abstract: Melatonin, the hormone of darkness, is a peculiar molecule found in most living organisms. Emerging as a potent broad-spectrum antioxidant, melatonin was repurposed into extra roles such as the modulation of circadian and seasonal rhythmicity,… read more here.
Keywords: gene modules; behavior parallels; melatonin; singularity cetacea ... See more keywords
Gene Modules Co-regulated with Biosynthetic Gene Clusters for Allelopathy between Rice and Barnyardgrass
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20163846
Abstract: Allelopathy is a central process in crop–weed interactions and is mediated by the release of allelochemicals that result in adverse growth effects on one or the other plant in the interaction. The genomic mechanism for… read more here.
Keywords: gene modules; rice barnyardgrass; biosynthetic gene; gene clusters ... See more keywords