Gene of the month: PRPF31
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DOI: 10.1136/jclinpath-2016-203971
Abstract: Pre-mRNA splicing is an essential process in eukaryotic cells where the transcribed intronic sequences are removed, prior to translation into protein. PRPF31 is a ubiquitously expressed splicing factor, which aids in the assembly of the… read more here.
Keywords: gene month; gene; month prpf31; pathology ... See more keywords
Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-206658
Abstract: The year 2020 has seen a major and sustained outbreak of a novel betacoronavirus (severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2) infection that causes fever, severe respiratory illness and pneumonia, a disease called COVID-19. At the… read more here.
Keywords: protein; cellular entry; gene month; spike protein ... See more keywords
Gene of the month: GLIS1-3
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2020-206859
Abstract: The GLIS 1–3 genes belong to a family of transcription factors, the Krüppel-like zinc finger proteins. The GLIS proteins function primarily as activators of transcription (GLIS 1 and 3), while GLIS 2 functions as a… read more here.
Keywords: gene month; month glis1; pathology; glis ... See more keywords
Gene of the month: NKX3.1
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DOI: 10.1136/jclinpath-2021-208073
Abstract: NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer,… read more here.
Keywords: month nkx3; gene month; pathology; histopathology ... See more keywords
Gene of the month: ERG
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208350
Abstract: The ERG gene belongs to the erythroblastosis transformation specific family of transcription factors and encodes for the transcription regulator protein ERG. It is located on chromosome 22q22 and is a nuclear transcription factor. In normal… read more here.
Keywords: gene month; transcription; month erg; gene ... See more keywords
Gene of the month: PALB2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208461
Abstract: The partner and localiser of BRCA2 (PALB2) gene, located on chromosome 16, functions as a tumour suppressor that plays a critical role in homologous recombination repair after DNA double-strand breaks. It encodes proteins involved in… read more here.
Keywords: gene month; palb2 gene; pathology; month palb2 ... See more keywords