Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.03.002
Abstract: Cell-to-cell variation in gene expression and the propagation of such variation (PoV or "noise propagation") from one gene to another in the gene network, as reflected by gene-gene correlation across single cells, are commonly observed… read more here.
Keywords: propagation; pov; variation; gene ... See more keywords
Synthetic Gene Network with Positive Feedback Loop Amplifies Cellulase Gene Expression in Neurospora crassa.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00011
Abstract: Second-generation or lignocellulosic biofuels are a tangible source of renewable energy, which is critical to combat climate change by reducing the carbon footprint. Filamentous fungi secrete cellulose-degrading enzymes called cellulases, which are used for production… read more here.
Keywords: positive feedback; neurospora crassa; gene expression; biology ... See more keywords
A gene network regulated by FGF signalling during ear development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05472-0
Abstract: During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling… read more here.
Keywords: fgf signalling; development; network; gene network ... See more keywords
A timer gene network is spatially regulated by the terminal system in the Drosophila embryo
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.26.477848
Abstract: In insect embryos, anteroposterior patterning is coordinated by the sequential expression of the “timer” genes caudal, Dichaete and odd-paired, whose expression dynamics correlate with the mode of segmentation. In Drosophila, the timer genes are expressed… read more here.
Keywords: gene network; timer gene; timer genes; gene ... See more keywords
sgnesR: An R package for simulating gene expression data from an underlying real gene network structure considering delay parameters
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1731-8
Abstract: BackgroundsgnesR (Stochastic Gene Network Expression Simulator in R) is an R package that provides an interface to simulate gene expression data from a given gene network using the stochastic simulation algorithm (SSA). The package allows… read more here.
Keywords: package; gene expression; expression; gene ... See more keywords
Activation of a gene network in durum wheat roots exposed to cadmium
Sign Up to like & getrecommendations! Published in 2018 at "BMC Plant Biology"
DOI: 10.1186/s12870-018-1473-4
Abstract: BackgroundAmong cereals, durum wheat (Triticum turgidum L. subsp. durum) accumulates cadmium (Cd) at higher concentration if grown in Cd-polluted soils. Since cadmium accumulation is a risk for human health, the international trade organizations have limited… read more here.
Keywords: gene network; cadmium; durum wheat; activation ... See more keywords
Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187546
Abstract: A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diversify regulatory potential is to combine multiple biochemical activities into the same protein.… read more here.
Keywords: determination gene; phosphatase; tyrosine phosphatase; eyes absent ... See more keywords
Identify clear cell renal cell carcinoma related genes by gene network
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22769
Abstract: Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential… read more here.
Keywords: cell; ccrcc; clear cell; gene network ... See more keywords
Gene network screening of bladder cancer via modular analysis
Sign Up to like & getrecommendations! Published in 2021 at "Translational cancer research"
DOI: 10.21037/tcr-20-2822
Abstract: Bladder cancer (BC) is one of the most common cancers of the urinary system. BC is the 13th most common cause of cancer-related death worldwide (1). The majority of BC is non-muscle invasive bladder cancers… read more here.
Keywords: bladder cancer; network screening; bladder; screening bladder ... See more keywords
Joint Lp-Norm and L2,1-Norm Constrained Graph Laplacian PCA for Robust Tumor Sample Clustering and Gene Network Module Discovery
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.621317
Abstract: The dimensionality reduction method accompanied by different norm constraints plays an important role in mining useful information from large-scale gene expression data. In this article, a novel method named Lp-norm and L2,1-norm constrained graph Laplacian… read more here.
Keywords: tumor sample; sample clustering; norm; graph laplacian ... See more keywords
Using a Gene Network of Pyroptosis to Quantify the Responses to Immunotherapy and Prognosis for Neuroblastoma Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.845757
Abstract: Background Pyroptosis, as an inflammatory form of cell death, is involved in many physiological and pathological processes. Neuroblastoma is the most common extra-cranial solid tumor in children. In this study, the relationship between pyroptosis and… read more here.
Keywords: gene network; prognosis; pyroptosis; neuroblastoma patients ... See more keywords