Are trait‐associated genes clustered together in a gene network?
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22557
Abstract: Genome‐wide association studies (GWAS) have provided an abundance of information about the genetic variants and their loci that are associated to complex traits and diseases. However, due to linkage disequilibrium (LD) and noncoding regions of… read more here.
Keywords: trait associated; trait; associated genes; gene network ... See more keywords
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.03.002
Abstract: Cell-to-cell variation in gene expression and the propagation of such variation (PoV or "noise propagation") from one gene to another in the gene network, as reflected by gene-gene correlation across single cells, are commonly observed… read more here.
Keywords: propagation; pov; variation; gene ... See more keywords
Synthetic Gene Network with Positive Feedback Loop Amplifies Cellulase Gene Expression in Neurospora crassa.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00011
Abstract: Second-generation or lignocellulosic biofuels are a tangible source of renewable energy, which is critical to combat climate change by reducing the carbon footprint. Filamentous fungi secrete cellulose-degrading enzymes called cellulases, which are used for production… read more here.
Keywords: positive feedback; neurospora crassa; gene expression; biology ... See more keywords
A gene network regulated by FGF signalling during ear development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05472-0
Abstract: During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling… read more here.
Keywords: fgf signalling; development; network; gene network ... See more keywords
The brain insulin receptor gene network and associations with frailty index
Sign Up to like & getrecommendations! Published in 2024 at "Age and Ageing"
DOI: 10.1093/ageing/afae091
Abstract: Abstract Objective To investigate longitudinal associations between variations in the co-expression-based brain insulin receptor polygenic risk score and frailty, as well as change in frailty across follow-up. Methods This longitudinal study included 1605 participants from… read more here.
Keywords: insulin receptor; receptor gene; frailty; gene network ... See more keywords
327 Beating the heat: Gene network analysis reveal the genetics of thermotolerance in Brangus cattle.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Animal Science"
DOI: 10.1093/jas/skaf300.039
Abstract: Heat stress is a major challenge in tropical and subtropical environments, negatively impacting both animal welfare and productivity. This underscores the need for thermotolerant cattle that can maintain internal body temperature and performance under heat-stress… read more here.
Keywords: heat; analysis; network analysis; thermotolerance ... See more keywords
A timer gene network is spatially regulated by the terminal system in the Drosophila embryo
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.26.477848
Abstract: In insect embryos, anteroposterior patterning is coordinated by the sequential expression of the “timer” genes caudal, Dichaete and odd-paired, whose expression dynamics correlate with the mode of segmentation. In Drosophila, the timer genes are expressed… read more here.
Keywords: gene network; timer gene; timer genes; gene ... See more keywords
sgnesR: An R package for simulating gene expression data from an underlying real gene network structure considering delay parameters
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1731-8
Abstract: BackgroundsgnesR (Stochastic Gene Network Expression Simulator in R) is an R package that provides an interface to simulate gene expression data from a given gene network using the stochastic simulation algorithm (SSA). The package allows… read more here.
Keywords: package; gene expression; expression; gene ... See more keywords
Activation of a gene network in durum wheat roots exposed to cadmium
Sign Up to like & getrecommendations! Published in 2018 at "BMC Plant Biology"
DOI: 10.1186/s12870-018-1473-4
Abstract: BackgroundAmong cereals, durum wheat (Triticum turgidum L. subsp. durum) accumulates cadmium (Cd) at higher concentration if grown in Cd-polluted soils. Since cadmium accumulation is a risk for human health, the international trade organizations have limited… read more here.
Keywords: gene network; cadmium; durum wheat; activation ... See more keywords
Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187546
Abstract: A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diversify regulatory potential is to combine multiple biochemical activities into the same protein.… read more here.
Keywords: determination gene; phosphatase; tyrosine phosphatase; eyes absent ... See more keywords
Identify clear cell renal cell carcinoma related genes by gene network
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22769
Abstract: Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential… read more here.
Keywords: cell; ccrcc; clear cell; gene network ... See more keywords