A large-scale benchmark of gene prioritization methods
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46598
Abstract: In order to maximize the use of results from high-throughput experimental studies, e.g. GWAS, for identification and diagnostics of new disease-associated genes, it is important to have properly analyzed and benchmarked gene prioritization tools. While… read more here.
Keywords: prioritization tools; network; gene prioritization; gene ... See more keywords
Benchmarking network-based gene prioritization methods for cerebral small vessel disease
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab006
Abstract: Abstract Network-based gene prioritization algorithms are designed to prioritize disease-associated genes based on known ones using biological networks of protein interactions, gene–disease associations (GDAs) and other relationships between biological entities. Various algorithms have been developed… read more here.
Keywords: network based; gene prioritization; disease; based gene ... See more keywords
Biological Random Walks: multi-omics integration for disease gene prioritization
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac446
Abstract: MOTIVATION Over the past decade, network-based approaches have proven useful in identifying disease modules within the human interactome, often providing insights into key mechanisms and guiding the quest for therapeutic targets. This is all the… read more here.
Keywords: random walks; disease; disease gene; biological random ... See more keywords
Scuba: scalable kernel-based gene prioritization
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2025-5
Abstract: BackgroundThe uncovering of genes linked to human diseases is a pressing challenge in molecular biology and precision medicine. This task is often hindered by the large number of candidate genes and by the heterogeneity of… read more here.
Keywords: kernel based; prioritization; gene prioritization; scalable kernel ... See more keywords