CCCTC‐Binding Factor Translates Interleukin 2‐ and &agr;‐Ketoglutarate‐Sensitive Metabolic Changes in T Cells into Context‐Dependent Gene Programs
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.07.015
Abstract: &NA; Despite considerable research connecting cellular metabolism with differentiation decisions, the underlying mechanisms that translate metabolite‐sensitive activities into unique gene programs are still unclear. We found that aspects of the interleukin‐2 (IL‐2)‐sensitive effector gene program… read more here.
Keywords: sensitive metabolic; gene programs; metabolic changes; agr sensitive ... See more keywords
Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac413
Abstract: Genome wide association studies provide statistical measures of gene-trait associations that reveal how genetic variation influences phenotypes. This study develops an unsupervised dimensionality reduction method called UnTANGLeD (Unsupervised Trait Analysis of Networks from Gene Level… read more here.
Keywords: trait associations; gene; analysis; diverse gene ... See more keywords
Hold the MYCrophone: MYC Invades Enhancers to Control Cancer Type Gene Programs.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-1376
Abstract: MYC is an oncogenic transcription factor that binds gene promoters to facilitate oncogenic gene expression. When overexpressed, as is the case in most human cancers, MYC also invades active enhancers-cis-regulatory elements that are critical for… read more here.
Keywords: cancer; cancer type; gene programs; myc ... See more keywords