Functional variants in the LC3B gene promoter in acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27035
Abstract: Acute myocardial infarction (AMI) is a common disease mainly caused by atherosclerosis, for which genetic causes remain largely unknown. Recently, low frequency and rare genetic variants have been proposed as risk factors. Autophagy has been… read more here.
Keywords: gene promoter; lc3b gene; ami patients; acute myocardial ... See more keywords
Association Between rs3833912/rs16944 SNPs and Risk for Cerebral Palsy in Mexican Children
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1178-6
Abstract: Perinatal asphyxia in the neonatal brain triggers a robust inflammatory response in which nitric oxide (NO) generation plays a hazardous role. Increased levels of NO can be maintained by the activity of inducible NO synthase… read more here.
Keywords: risk cerebral; cerebral palsy; gene promoter; risk ... See more keywords
Exploring IL-17 gene promoter polymorphisms in canine leishmaniasis.
Sign Up to like & getrecommendations! Published in 2022 at "Acta tropica"
DOI: 10.1016/j.actatropica.2022.106452
Abstract: Proinflammatory cytokine secretion determines the infection course in leishmaniasis. The immunopathology of canine leishmaniasis (CanL) caused by Leishmania infantum is characterized by low Leishmania-specific IFN-γ and IL-17 production. Mutations in the human IL-17 gene promoter… read more here.
Keywords: canine leishmaniasis; exploring gene; gene promoter; leishmaniasis ... See more keywords
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of aging"
DOI: 10.1016/j.neurobiolaging.2021.06.011
Abstract: Our previous study suggests that upregulated RAB35 is implicated in etiology of Parkinson's disease (PD). We hypothesized that upregulated RAB35 results from single nucleotide polymorphisms (SNPs) in RAB35 gene promoter. We identified SNPs within RAB35… read more here.
Keywords: gene promoter; within rab35; rs17525453 within; rab35 gene ... See more keywords
Gene promoter polymorphisms in boar spermatozoa differing in freezability.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.02.018
Abstract: Single nucleotide polymorphisms (SNPs) in the 5'-flanking regulatory regions of genes could affect their expression levels. This is a follow-up study aimed to identify polymorphic variants in the 5'-flanking regulatory regions of genes expressed in… read more here.
Keywords: gene promoter; polymorphic variants; boar spermatozoa; gene ... See more keywords
PM2.5 exposure and cold stress exacerbates asthma in mice by increasing histone acetylation in IL-4 gene promoter in CD4+ T cells.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.09.011
Abstract: Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects… read more here.
Keywords: gene promoter; cd4 cells; promoter cd4; gene ... See more keywords
PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12770
Abstract: Aberrant expression of PDGFR-β is associated with a number of diseases. The G-quadruplexes (G4s) formed in PDGFR-β gene promoter are transcriptional modulators and amenable to small molecule targeting. The major G4 formed in the PDGFR-β… read more here.
Keywords: gene promoter; promoter; vacancy; structure ... See more keywords
Correlations of TNF-α gene promoter polymorphisms with the risk of thymoma-associated myasthenia gravis in a northern Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2017.13
Abstract: This study was performed with the aim to investigate the correlations of tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms with the risk of thymoma-associated myasthenia gravis (T-MG) in a northern Chinese Han population. Between June… read more here.
Keywords: gene promoter; promoter polymorphisms; group; tnf gene ... See more keywords
Associations between TNF gene promoter variants (rs361525, rs1800629, rs1799964, rs1799724) and the clinical course of idiopathic inflammatory myopathies
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-25258-z
Abstract: Idiopathic inflammatory myopathies (IIM) are characterized by muscle weakness and immune-mediated muscle injury. Tumor necrosis factor (TNF) appears to be involved in the pathogenesis of IIM, especially regarding susceptibility to malignancy. Here, we analyzed associations… read more here.
Keywords: rs1799964; idiopathic inflammatory; gene; tnf gene ... See more keywords
Polymorphic potential of SRF binding site of c-Fos gene promoter: in vitro study
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra05897f
Abstract: Recently published in vivo observations have highlighted the presence of cruciform structures within the genome, suggesting their potential significance in the rapid recognition of the target sequence for transcription factor binding. In this in vitro… read more here.
Keywords: site; vitro study; fos gene; gene promoter ... See more keywords
MO031KLOTHO GENE PROMOTER METHYLATION IN THE VASCULATURE IS RELATED TO INFLAMMATION IN HUMAN ATHEROSCLEROSIS
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab080.003
Abstract: Atherosclerosis, a vascular pathological process with an important inflammatory component, underlies most of the cardiovascular diseases (CVD). Deficiencies in the antiaging factor α-Klotho (KL) have been related to the appearance and progression of atherosclerotic damage… read more here.
Keywords: inflammatory; expression; gene promoter; methylation ... See more keywords