Dynamic alterations of H3K4me3 and H3K27me3 at ADAM17 and Jagged-1 gene promoters cause an inflammatory switch of endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30579
Abstract: Histone protein modifications control the inflammatory state of many immune cells. However, how dynamic alteration in histone methylation causes endothelial inflammation and apoptosis is not clearly understood. To examine this, we explored two contrasting histone… read more here.
Keywords: gene promoters; adam17 jagged; inflammation; endothelial inflammation ... See more keywords
Chromatin Regulation at Parental Gene Promoters by Pseudogene Sense lncRNAs.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1503-4_13
Abstract: There is accumulating evidence that pseudogenes can produce functionally relevant lncRNAs in a tightly controlled manner. This class of transcripts has been demonstrated to play an important role in development and disease, by controlling parental… read more here.
Keywords: parental gene; gene promoters; chromatin; sense ... See more keywords
The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.07.001
Abstract: Synovial fibroblasts (SF) drive inflammation and joint destruction in chronic arthritis. Here we show that SF possess a distinct type of LPS tolerance compared to macrophages and other types of fibroblasts. In SF and dermal… read more here.
Keywords: type; lps tolerance; specific lps; gene promoters ... See more keywords
HIF‐dependent and reversible nucleosome disassembly in hypoxia‐inducible gene promoters
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.03.020
Abstract: ABSTRACT Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia‐inducible transcription has been analyzed for use as a model system of stress‐inducible gene regulation. In this study, changes in chromatin organization… read more here.
Keywords: transcription; gene promoters; gene; inducible gene ... See more keywords
Vimentin binds to G-quadruplex repeats found at telomeres and gene promoters
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1274
Abstract: Abstract G-quadruplex (G4) structures that can form at guanine-rich genomic sites, including telomeres and gene promoters, are actively involved in genome maintenance, replication, and transcription, through finely tuned interactions with protein networks. In the present… read more here.
Keywords: gene promoters; vimentin binds; telomeres gene; gene ... See more keywords
Cooperative activation of the human herpesvirus 6B U79/80 early gene promoter by immediate‐early proteins IE1B and IE2B
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12844
Abstract: The human herpesvirus 6B (HHV‐6B) U79/80 gene belongs to the early gene class and appears as early as 3 hr postinfection. It is one of the most abundantly expressed transcripts and a useful diagnostic marker for… read more here.
Keywords: gene promoters; u79 early; early gene; activation ... See more keywords
Dose Dependence of Hypermethylation of Gene Promoters in Blood Leukocytes in Humans Occupationally Exposed to External γ-Radiation
Sign Up to like & getrecommendations! Published in 2019 at "Biology Bulletin"
DOI: 10.1134/s1062359019110062
Abstract: Abstract—A study of promoter hypermethylation of cell cycle (RASSF1A, p16/INK4A, p14/ARF, p53, АТМ), xenobiotic detoxification (GSTP1), antioxidant defense (SOD3), and estrogen receptor (ESR1) genes in blood leukocytes of 88 nuclear industry workers from the Mayak… read more here.
Keywords: hypermethylation; gene promoters; radiation; external radiation ... See more keywords
Associations of polymorphisms in the gene promoters of cytokines and matrix metalloproteinases with bone mineral density in postmenopausal type 2 diabetic women
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes mellitus"
DOI: 10.14341/dm8825
Abstract: Background . Osteoporosis and type 2 diabetes are common comorbidities in postmenopausal women. An important role in the bone remodeling over the menopausal transition can be played by cytokines and matrix metalloproteinases (MMPs). It was… read more here.
Keywords: gene promoters; promoters cytokines; bmd; position ... See more keywords
Methylation of Immune Gene Promoters in Oral and Oropharyngeal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097698
Abstract: The proportion of oral and oropharyngeal squamous cell carcinoma (OOSCC) that can be attributed to human papillomavirus (HPV) infection is growing nowadays. A potential factor indicating the occurrence of HPV-positive OSCC is a change in… read more here.
Keywords: methylation; oropharyngeal cancer; oral oropharyngeal; gene ... See more keywords
Methylation of APC2, NR3C1, and DRD2 gene promoters in turkish patients with tobacco use disorder
Sign Up to like & getrecommendations! Published in 2022 at "Nigerian Journal of Clinical Practice"
DOI: 10.4103/njcp.njcp_25_21
Abstract: Background: Many studies have investigated the association of the methylation of gene and tobacco use disorders (TUD), but results remain ambiguous. Aims: This study evaluated the relationship between methylation of Adenomatosis Polyposis Coli (APC), Nuclear… read more here.
Keywords: tobacco use; methylation; methylation apc2; drd2 gene ... See more keywords
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36435
Abstract: We have examined the role of Fam60a, a gene highly expressed in embryonic stem cells, in mouse development. Fam60a interacts with components of the Sin3a-Hdac transcriptional corepressor complex, and most Fam60a–/– embryos manifest hypoplasia of… read more here.
Keywords: methylation; gene promoters; fam60a embryos; fam60a ... See more keywords