Plasma calcitonin gene‐related peptide (CGRP) in migraine and endometriosis during the menstrual cycle
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51360
Abstract: Migraine, endometriosis, and the comorbidity of both are frequent pain disorders of special relevance for women. The neuropeptide calcitonin gene‐related peptide (CGRP) is critically involved in migraine, and circumstantial evidence suggests a role in endometriosis.… read more here.
Keywords: endometriosis; related peptide; gene related; calcitonin gene ... See more keywords
Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103005
Abstract: The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical… read more here.
Keywords: fracture; electrical stimulation; gene related; fracture healing ... See more keywords
Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25831
Abstract: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. read more here.
Keywords: antagonists worsen; related peptide; gene related; calcitonin gene ... See more keywords
Efficacy and safety of calcitonin gene‐related peptide antagonists in migraine treatment: A meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2542
Abstract: We systematically reviewed the efficacy and safety of Calcitonin Gene‐Related Peptide (CGRP) antagonists for migraine treatment. read more here.
Keywords: calcitonin gene; safety calcitonin; related peptide; antagonists migraine ... See more keywords
Calcitonin gene‐related peptide: An intra‐articular therapeutic target for TMJ disorders
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.606
Abstract: The goal of this project was to evaluate the role of calcitonin gene‐related peptide (CGRP) in the development of arthritis. read more here.
Keywords: calcitonin gene; related peptide; intra articular; peptide intra ... See more keywords
Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_173
Abstract: The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as receptor activity modifying protein type 1 (RAMP1). The levels of… read more here.
Keywords: cgrp; related peptide; gene related; calcitonin gene ... See more keywords
Is calcitonin gene-related peptide a modulator of menopausal vasomotor symptoms?
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1777-z
Abstract: PurposeCalcitonin gene-related peptide (CGRP) is a neuropeptide widely distributed in the central and peripheral nervous systems, which is known as a potent vasodilator. Postmenopausal women who experience hot flushes have high levels of plasma CGRP,… read more here.
Keywords: menopausal vasomotor; cgrp; related peptide; gene related ... See more keywords
A new era for migraine: The role of calcitonin gene-related peptide in the trigeminovascular system.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2020.05.012
Abstract: There is a huge improvement in our understanding of migraine pathophysiology in the past decades. The activation of the trigeminovascular system has been proved to play a key role in migraine. Calcitonin gene-related peptide (CGRP)… read more here.
Keywords: migraine; trigeminovascular system; cgrp; gene related ... See more keywords
Calcitonin gene-related peptide (CGRP)-targeted therapies as preventive and acute treatments for migraine-The monoclonal antibodies and gepants.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2020.06.019
Abstract: Calcitonin Gene-Related Peptide (CGRP) plays a pivotal role in migraine pathophysiology. Two types of CGRP function-blocking modalities, monoclonal antibodies, and small molecules (gepants), have been developed to target the CGRP ligands and CGRP receptors. Four… read more here.
Keywords: monoclonal antibodies; cgrp; related peptide; gene related ... See more keywords
Secretoneurin and PE-11 immunoreactivity in the human dental pulp.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.11.005
Abstract: OBJECTIVE To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin… read more here.
Keywords: secretoneurin; human dental; gene related; calcitonin gene ... See more keywords
α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.06.024
Abstract: Objective Although it is well established that a-calcitonin gene-related peptide (CGRP) stabilizes muscle-type cholinergic receptors nicotinic subunits (AChR), the underlying mechanism by which this neuropeptide regulates muscle protein metabolism and neuromuscular junction (NMJ) morphology is… read more here.
Keywords: autophagy calpain; related peptide; gene related; calcitonin gene ... See more keywords